NDLI: Application of chemokine receptor antagonist with stents reduces local inflammation and suppresses cancer growth.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mao, Ai-Wu Jiang, Ting-Hui Sun, Xian-Jun Peng, Jian
Description	Country affiliation: China Author Affiliation: Mao AW ( Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, 410008, China.); Jiang TH ( Interventional Center, St. Luke's Hospital of Jiaotong University School of Medicine, 786 Yuyuan Road, Shanghai, 200050, China.); Sun XJ ( Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, 410008, China.); Peng J ( Interventional Center, St. Luke's Hospital of Jiaotong University School of Medicine, 786 Yuyuan Road, Shanghai, 200050, China.)
Abstract	Severe pain and obstructive jaundice resulting from invasive cholangiocarcinoma or pancreatic carcinoma can be alleviated by implantation of biliary and duodenal stents. However, stents may cause local inflammation to have an adverse effect on the patients' condition and survival. So far, no efficient approaches have been applied to prevent the occurrence of stents-related inflammation. Here, we reported significantly higher levels of serum stromal cell-derived factor 1 (SDF-1) in the patients that developed stents-associated inflammation. A higher number of inflammatory cells have been detected in the cancer close to stent in the patients with high serum SDF-1. Since chemokine plays a pivotal role in the development of inflammation, we implanted an Alzet osmotic pump with the stents to gradually release AMD3100, a specific inhibitor binding of SDF-1 and its receptor C-X-C chemokine receptor 4 (CXCR4), at the site of stents in mice that had developed pancreatic cancer. We found that AMD3100 significantly reduced local inflammation and significantly inhibited cancer cell growth, resulting in improved survival of the mice that bore cancer. Moreover, the suppression of cancer growth may be conducted through modulation of CyclinD1, p21, and p27 in the cancer cells. Together, these data suggest that inhibition of chemokine signaling at the site of stents may substantially improve survival through suppression of stent-related inflammation and tumor growth.
File Format	HTM / HTML
ISSN	10104283
Issue Number	11
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Chemokine Cxcl12 Genetics Inflammation Drug Therapy Pancreatic Neoplasms Receptors, Cxcr4 Stents Adverse Effects Animals Cell Line, Tumor Cell Proliferation Drug Effects Antagonists & Inhibitors Heterocyclic Compounds Administration & Dosage Humans Chemically Induced Mice Neoplasms, Experimental Pathology Metabolism Signal Transduction Xenograft Model Antitumor Assays Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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