NDLI: Prognostic significance of Nemo-like kinase expression in patients with hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Hong-Wei Qiao, Hong-Ying Li, Hong-Chen Li, Zong-Feng Zhang, Hong-Juan Pei, Liu Liu, Hong-Wei Jin, Liang Wang, Dong Li, Jun-Liang
Description	Country affiliation: China Author Affiliation: Chen HW ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China. hongweichen0306@outlook.com.); Qiao HY ( Department of Allergy, The First Hospital of Qinhuangdao, Qinhuangdao, China.); Li HC ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Li ZF ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Zhang HJ ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Pei L ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Liu HW ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Jin L ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Wang D ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.); Li JL ( Department of Clinical Laboratory, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, China.)
Abstract	Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine protein kinase and belongs to the extracellular signal-regulated kinases/microtubule-associated protein kinase families (Erks/MAPKs). Previous studies have indicated that abnormal expressions of NLK played critical roles in various types of human cancers. Recent studies suggested that NLK expression was significantly upregulated in the hepatocellular carcinoma (HCC) specimens. However, the clinical significance of NLK expression in HCC remains largely unknown. In this study, we focused on the clinical significance of NLK in HCC and found that high expression of NLK was significantly associated with Edmondson-Steiner grade (P = 0.002), tumor size (P = 0.022), and no. of tumor nodules (P < 0.001), and NLK was positively correlated with proliferation marker Ki-67 (P < 0.01). Univariate analysis suggested that NLK expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that NLK expression was an independent prognostic indicator for HCC (P = 0.0370). In conclusion, NLK overexpression is associated with poor overall survival in patients with HCC, it might be an independent poor prognostic marker for HCC.
File Format	HTM / HTML
ISSN	10104283
Issue Number	11
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Tumor Markers, Biological Biosynthesis Intracellular Signaling Peptides And Proteins Liver Neoplasms Genetics Prognosis Protein-serine-threonine Kinases Adult Aged Cell Line, Tumor Cell Proliferation Female Gene Expression Regulation, Neoplastic Humans Kaplan-meier Estimate Pathology Male Middle Aged Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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