NDLI: Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hwang, Jung Soon Lee, Hai-Chon Oh, Sang Cheul Lee, Dae-Hee Kwon, Ki Han
Description	Author Affiliation: Hwang JS ( Division of Cosmetic Arts, Department of Culture Service, Graduate School of Culture and Arts, Dongguk University, Seoul, Republic of Korea.); Lee HC ( Wide River Institute of Immunology, Seoul National University, Seoul, Gangwon, Republic of Korea.); Oh SC ( Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.); Lee DH ( Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. leedneo@gmail.com.); Kwon KH ( Department of Surgery and Pharmacology and Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. leedneo@gmail.com.)
Abstract	In this study, we showed the ability of representative shogaol, which as a major component of ginger, to overcome TRAIL resistance by increasing apoptosis in colon cancer cells. Shogaol increased death receptor 5 (DR5) levels. Furthermore, shogaol decreased the expression level of antiapoptotic proteins (survivin and Bcl-2) and increased pro-apoptotic protein, Bax. Shogaol treatment induced apoptosis and a robust reduction in the levels of the antiapoptotic protein survivin but did not affect the levels of many other apoptosis regulators. Moreover, knockdown of survivin sensitized colon cancer cells to resistant of TRAIL-induced apoptosis. Therefore, we showed the functions of shogaol as a sensitizing agent to induce cell death of TRAIL-resistant colon cancer cells. This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.
File Format	HTM / HTML
ISSN	10104283
Issue Number	11
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Catechols Administration & Dosage Colonic Neoplasms Genetics Inhibitor Of Apoptosis Proteins Receptors, Tnf-related Apoptosis-inducing Ligand Biosynthesis Tnf-related Apoptosis-inducing Ligand Apoptosis Drug Effects Chemistry Cell Line, Tumor Drug Therapy Pathology Drug Resistance, Neoplasm Drug Synergism Ginger Humans Proto-oncogene Proteins C-bcl-2 Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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