NDLI: Process development for the decoloration of Panax notoginseng extracts: a design space approach.

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Process development for the decoloration of Panax notoginseng extracts: a design space approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Teng Gong, Xingchu Chen, Huali Qu, Haibin
Description	Country affiliation: China Author Affiliation: Chen T ( Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.)
Abstract	A systematic, yet simple method for the decoloration of Panax notoginseng extracts has been developed by static adsorption tests and response surface methodology. Through static adsorption experiment screening, acidic alumina was selected because of its high decoloration ratio and saponin recovery ratios. Using response surface methodology, the correlation between the process parameters (i.e., sample volume and flow rate) and decoloration performance was modeled. A design space of the decoloration process was subsequently established through the proposed models. The verification experimental values were in good agreement with the predicted values. The design space was proven reliable, because all the verification experimental results attained the criteria for design space development. Moreover, most of the saponins adsorbed by the acidic alumina could be recovered through dynamic desorption using water and ethanol. The method developed in the current study is highly efficient, flexible, and easy to control, thus providing a promising approach for the decoloration of Panax notoginseng extracts with consistent decoloration performance.
File Format	HTM / HTML
ISSN	16159306
Issue Number	2
Journal	Journal of Separation Science
Volume Number	38
e-ISSN	16159314
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-01-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Color Drugs, Chinese Herbal Chemistry Adsorption Saponins Surface Properties Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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Chromatographic elution process design space development for the purification of saponins in Panax notoginseng extract using a probability-based approach.

Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines.

Fast determination of four active compounds in Sanqi Panax Notoginseng Injection samples by high-performance liquid chromatography with a chemometric method.

Fast determination of ginsenosides in ginseng by high-performance liquid chromatography with chemometric resolution.

Isolation of four high-purity dammarane saponins from extract of Panax notoginseng by centrifugal partition chromatography coupled with evaporative light scattering detection in one operation.

Simultaneous quantitative analysis of nine triterpenoid saponins for the quality control of Stauntonia obovatifoliola Hayata subsp. intermedia stems.

Preparative enrichment and separation of astragalosides from Radix Astragali extracts using macroporous resins.

Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells.

Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng.

Process development for the decoloration of Panax notoginseng extracts: a design space approach.

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Chromatographic elution process design space development for the purification of saponins in Panax notoginseng extract using a probability-based approach.

Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines.

Fast determination of four active compounds in Sanqi Panax Notoginseng Injection samples by high-performance liquid chromatography with a chemometric method.

Fast determination of ginsenosides in ginseng by high-performance liquid chromatography with chemometric resolution.

Isolation of four high-purity dammarane saponins from extract of Panax notoginseng by centrifugal partition chromatography coupled with evaporative light scattering detection in one operation.

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Preparative enrichment and separation of astragalosides from Radix Astragali extracts using macroporous resins.

Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells.

Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng.

Process development for the decoloration of Panax notoginseng extracts: a design space approach.