NDLI: A fully validated method for the determination of lacosamide in human plasma using gas chromatography with mass spectrometry: application for therapeutic drug monitoring.

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A fully validated method for the determination of lacosamide in human plasma using gas chromatography with mass spectrometry: application for therapeutic drug monitoring.

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A fully validated method for the determination of lacosamide in human plasma using gas chromatography with mass spectrometry: application for therapeutic drug monitoring.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nikolaou, Panagiota Papoutsis, Ioannis Spiliopoulou, Chara Voudris, Constantinos Athanaselis, Sotiris
Description	Country affiliation: Greece Author Affiliation: Nikolaou P ( Faculty of Medicine, Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Greece.)
Abstract	A simple gas chromatographic method with mass spectrometry detection was developed and validated for the determination of lacosamide in human plasma. Lacosamide and the internal standard, levetiracetam-d6, were extracted from 200 µL plasma, by a solid-phase extraction through HF Bond Elut C18 columns, and derivatized using N-methyl-N-tert-butyldimethylsilyltrifluoroacetamide with 1% tert-butyldimethylsilylchloride in acetonitrile. The limit of quantification was found to be 0.20 µg/mL and the assay was linear up to 20.0 µg/mL with correlation coefficient ≥0.994. The intra- and interday precision values were <4.1% in terms of relative standard deviation (%) and the values of intra- and interday accuracy were found to be within -7.2 and 5.3% in terms of relative error (%). Absolute recovery of the method for lacosamide was determined at three concentration levels and ranged from 92.5 to 97.6%. The developed method uses small volumes of plasma and proved to be simple, rapid, and sensitive for the determination of lacosamide in plasma. This method can be used in routine every day analysis of plasma samples obtained from patients who follow respective antiepileptic treatment and for the investigation of clinical and forensic cases where lacosamide is involved.
File Format	HTM / HTML
ISSN	16159306
Issue Number	2
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-01-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Acetamides Blood Anticonvulsants Drug Monitoring Methods Epilepsy Drug Therapy Gas Chromatography-mass Spectrometry Therapeutic Use Calibration Humans Quality Control Journal Article Validation Studies
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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A fully validated method for the determination of lacosamide in human plasma using gas chromatography with mass spectrometry: application for therapeutic drug monitoring.

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