NDLI: Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng.

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Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qian, Mao Yi, Li Song-Lin, Li Jie, Yang Ping-Hu, Zhang Qiang, Wang
Description	Country affiliation: China Author Affiliation: Qian M ( Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210009, China.); Yi L ( Nanjing Normal University Center for Analysis and Testing, Nanjing Normal University, Nanjing 210009, China.); Song-Lin L ( Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210009, China.); Jie Y ( State Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.); Ping-Hu Z ( Jiangsu Center for New Drug Screening & National New Drug Screening Laboratory, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhangpinghu@163.com.); Qiang W ( State Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: qwang49@126.com.)
Abstract	AIM: To evaluate the chemical profiles and cytotoxic effects among the total saponin fraction (TSF), 25% ethanol fraction (25EF), 50% ethanol fraction (50EF), and 85% ethanol fraction (85EF) prepared by macroporous resin from the leaves of Panax notoginseng. METHOD: The simultaneous determination of thirteen main saponins, as well as the chemical profiles of saponin fractions of different polarity, was made by HPLC-DAD and LC-ESI-MS(n) analysis. The cytotoxic effects were determined against KP4 cells (human pancreatic cancer), NCI-H727 cells (human lung cancer), HepG2 cells (human hepatocellular cancer), and SGC-7901 cells (human gastric adenocarcinoma). RESULTS: Chemical analysis indicated that 85EF possessed the most abundant cytotoxic protopanaxadiol saponins, including the marker saponins F2, 20(R)-Rg3, 20(S)-Rg3, and Rh2. The MTT assay showed that 85EF also had the strongest cytotoxic effects among the four fractions. 25EF showed no anti-proliferative effects, while 50EF and TSF exhibited weak anti-proliferative activity. CONCLUSION: From the aspect of comprehensive utilization of resources, 85EF, enriched with low polarity PPD group saponins, is a new alternative source of anticancer saponins, and a promising botanical preparation for further anticancer studies.
File Format	HTM / HTML
ISSN	20956975
Issue Number	1
Volume Number	12
e-ISSN	18755364
Journal	Chinese Journal of Natural Medicines
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	China
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Antineoplastic Agents, Phytogenic Chemistry Pharmacology Drugs, Chinese Herbal Panax Notoginseng Plant Leaves Saponins Cell Line, Tumor Cell Proliferation Drug Effects Chromatography, High Pressure Liquid Humans Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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