NDLI: Liquid chromatography-tandem mass spectrometry for quantification of lacosamide, an antiepileptic drug, in rat plasma and its application to pharmacokinetic study.

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Liquid chromatography-tandem mass spectrometry for quantification of lacosamide, an antiepileptic drug, in rat plasma and its application to pharmacokinetic study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Soo-Jin Koo, Tae-Sung Ha, Dong-Jin Baek, Myoungki Lee, Sang-Kil Shin, Dong-Soo Moon, Hongsik
Description	Author Affiliation: Kim SJ ( Life Science R&D Park, SK Holdings Co. Ltd, Daejeon, 305-712, Korea.)
Abstract	A rapid, simple and sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) was developed for the determination of an antiepileptic drug, lacosamide, in rat plasma. The method involves the addition of acetonitrile and internal standard solution to plasma samples, followed by centrifugation. An aliquot of the supernatant was diluted with water and directly injected into the LC/MS/MS system. The separations were performed on column packed with octadecylsilica (5 µm, 2.0 × 50 mm) with 0.1% formic acid and acetonitrile as mobile phase, and the detection was performed on tandem mass spectrometry by the multiple-reaction monitoring via an electrospray ionization source. The standard curve was linear over the concentration range from 0.3 to 1000 ng/mL. The lower limit of quantification was 0.3 ng/mL using 50 µL of rat plasma sample. The intra- and inter-assay precision and accuracy were found to be less than 11.7 and 8.8%, respectively. The developed analytical method was successfully applied to the pharmacokinetic study of lacosamide in rats.
File Format	HTM / HTML
ISSN	02693879
Issue Number	3
Volume Number	26
e-ISSN	10990801
Journal	Biomedical Chromatography
Language	English
Publisher	Wiley
Publisher Date	2012-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Chemistry Discipline Molecular Biology Discipline Biochemistry Discipline Pharmacology Acetamides Blood Anticonvulsants Chromatography, High Pressure Liquid Methods Tandem Mass Spectrometry Pharmacokinetics Animals Area Under Curve Limit Of Detection Rats Reference Standards Journal Article Validation Studies
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Drug Discovery Clinical Biochemistry Biochemistry Molecular Biology Pharmacology

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