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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Zhi Kong, Xiangzhen Zuo, Lihua Kang, Jian Hou, Lei Zhang, Xiaojian |
| Description | Author Affiliation: Sun Z ( Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.); Kong X ( Key subject Laboratory of clinical medicine of colleges and universities in Henan province, Zhengzhou, Henan Province, P. R. China.); Zuo L ( Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.); Kang J ( Key subject Laboratory of clinical medicine of colleges and universities in Henan province, Zhengzhou, Henan Province, P. R. China.); Hou L ( Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.); Zhang X ( Key subject Laboratory of clinical medicine of colleges and universities in Henan province, Zhengzhou, Henan Province, P. R. China.) |
| Abstract | A novel and rapid microwave extraction and ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of 25 bioactive constituents (including two new constituents) in Fructus Alpinia oxyphylla. The optimized conditions of the microwave extraction was a microwave power of 300 W, extraction temperature of 80°C, solvent-to-solid ratio of 30 mL/g and extraction time of 8 min. Separation was achieved on a Waters ACQUITY UPLC(®) HSS C18 column (2.1 mm× 50 mm, 1.8 µm) using gradient elution with a mobile phase consisting of acetonitrile and 1 mM ammonium acetate at a flow rate of 0.2 mL/min. This is the first report of the simultaneous determination of 25 bioactive constituents in Fructus Alpinia oxyphylla by ultra high performance liquid chromatography with tandem mass spectrometry. The method was validated with good linearity, acceptable precision and accuracy. The validated method was successfully applied to determine the contents of 25 bioactive constituents in Fructus Alpinia oxyphylla from different sources and the analysis results were classified by hierarchical cluster analysis, which indicated the effect of different cultivation regions on the contents of constituents. This study provides powerful and practical guidance in the quality control of Alpinia oxyphylla and lays the foundation for further research of Alpinia oxyphylla. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2016-02-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Alpinia Chemistry Chromatography, High Pressure Liquid Methods Microwaves Tandem Mass Spectrometry Limit Of Detection Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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