NDLI: Cecropia obtusifolia Bertol and its active compound, chlorogenic acid, stimulate 2-NBDglucose uptake in both insulin-sensitive and insulin-resistant 3T3 adipocytes.

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Cecropia obtusifolia Bertol and its active compound, chlorogenic acid, stimulate 2-NBDglucose uptake in both insulin-sensitive and insulin-resistant 3T3 adipocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alonso-Castro, Angel Josabad Miranda-Torres, Ana Cristina González-Chávez, Marco Martín Salazar-Olivo, Luis A.
Spatial Coverage	Mexico
Description	Author Affiliation: Alonso-Castro AJ ( Instituto Potosino de Investigación Científica y Tecnológica, División de Biología Molecular, San Luis Potosí, SLP, México.)
Abstract	ETHNOPHARMACOLOGICAL IMPORTANCE: Cecropia obtusifolia Bertol (Cecropiaceae) is a plant extensively used for the empirical treatment of type 2 diabetes in México. Although some of its hypoglycemic principles have been described, their mechanisms of action remain unclear. AIM OF THE STUDY: To investigate the anti-diabetic mechanisms of Cecropia obtusifolia aqueous extract (CAE) and its active compound chlorogenic acid (CGA). MATERIALS AND METHODS: Non-toxic concentrations of CAE and CGA were assayed on the adipogenesis and 2-NBDglucose uptake in 3T3-F442A murine adipocytes. RESULTS: Added to adipogenic medium, CAE 70 microg/ml induced a modest increment (20%) in 3T3 adipogenesis whereas CGA did not affect adipogenesis at any of the tested concentrations (0.1-100 microM). Both preparations stimulated 2-NBDG uptake in adipocytes by 51% (CAE) and 176% (CGA) in the absence of insulin, and by 174% (CAE) and 404% (CGA) in the presence of the hormone. CAE and CGA also stimulated the 2-NBDG uptake in insulin-resistant 3T3 adipocytes by 35% and 141%, respectively, compared with the incorporation shown by insulin-sensitive adipocytes stimulated by the hormone. The potency of CGA to stimulate 2-NBDG uptake was comparable to the anti-diabetic drug rosiglitazone. CONCLUSION: Cecropia obtusifolia and CGA exert their anti-diabetic effects stimulating glucose uptake in both insulin-sensitive and insulin-resistant adipocytes without appreciable pro-adipogenic effects.
File Format	HTM / HTML
ISSN	03788741
Issue Number	3
Volume Number	120
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2008-12-08
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology 4-chloro-7-nitrobenzofurazan Analogs & Derivatives Cecropia Plant Chemistry Chlorogenic Acid Pharmacology Deoxyglucose Hypoglycemic Agents Insulin Metabolism Plant Extracts Adipocytes Drug Effects Adipogenesis Analysis Of Variance Animals Cell Line Therapeutic Use Chromatography, High Pressure Liquid Diabetes Mellitus, Type 2 Drug Therapy Insulin Resistance Mexico Mice Phytotherapy Plant Structures Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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Cecropia obtusifolia Bertol and its active compound, chlorogenic acid, stimulate 2-NBDglucose uptake in both insulin-sensitive and insulin-resistant 3T3 adipocytes.