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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Geraghty, Dominic P. Ahuja, Kiran D. K. Pittaway, Jane Shing, Cecilia Jacobson, Glenn A. Jager, Nynke Jurkovic, Sasa Narkowicz, Christian Saunders, Cassandra I. Ball, Madeleine Pinkard, Alex Vennavaram, Raghu R. Adams, Murray J. |
| Description | Country affiliation: Australia Author Affiliation: Geraghty DP ( School of Human Life Sciences, University of Tasmania, Locked Bag 1320, Launceston, Tasmania 7250, Australia. D.Geraghty@utas.edu.au) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Carpobrotus rossii (CR) has a history of use as a food and therapeutic agent by Australian indigenous peoples and early European settlers and is believed to contain a number of pharmacologically active polyphenolic compounds. AIMS OF THE STUDY: Oxidation of low density lipoprotein (LDL), platelet aggregation, and inflammation contribute to the development and progression of atherosclerosis. The aim of the present study was to investigate the antioxidant, antiplatelet and anti-inflammatory activity of CR extract using human blood components. MATERIALS AND METHODS: An assay employing in vitro copper-induced oxidation of serum lipids was used to assess antioxidant activity of CR extract (and tannin, flavonoid and pre- and post-flavonoid fractions). The effects of CR extract on ADP- and collagen-induced platelet aggregation, and on basal (unstimulated) and lipopolysaccharide (LPS)- and phytohaemagglutinin A (PHA)-stimulated cytokine release from peripheral blood mononuclear cells (PBMC) were also investigated. RESULTS: CR extract increased the lag time of serum oxidation (maximum of â¼4-fold at 20µg/ml) in a concentration-dependent manner. The antioxidant activity resided only in the tannin and post-flavonoid fractions. CR had no effect on ADP-induced platelet aggregation, but significantly decreased collagen-induced platelet aggregation. LPS, but not PHA, significantly increased the release of IL-1ß and TNF- from PBMC. CR extract alone inhibited monocyte chemoattractant protein (MCP)-1 release and in the presence of LPS, inhibited IL-10, TNF- and MCP-1 release compared to LPS alone. CONCLUSION: CR has significant in vitro antioxidant, antiplatelet and, potentially, anti-inflammatory activity. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 134 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-03-08 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Anti-inflammatory Agents Pharmacology Antioxidants Plant Extracts Plants, Medicinal Chemistry Platelet Aggregation Inhibitors Cytokines Metabolism Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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