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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hseu, You-Cheng Chen, Ssu-Ching Lin, Wen-Hsin Hung, Dong-Zong Lin, Ming-Kuem Kuo, Yueh-Hsiung Wang, Mei-Tsun Cho, Hsin-Ju Wang, Lai Yang, Hsin-Ling |
| Description | Country affiliation: Taiwan Author Affiliation: Hseu YC ( Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung, Taiwan.) |
| Abstract | AIM OF THE STUDY: Toona sinensis is well known as a traditional Chinese medicine; also, it has been shown to exhibit anticancer and anti-inflammatory effects. This study was aimed at evaluating the anti-angiogenesis effect of the aqueous extracts of Toona sinensis (TS extracts) or gallic acid, a major component of TS extracts, against both VEGF-induced EA.hy 926 and human umbilical vein endothelial cells (HUVECs). MATERIALS AND METHODS: Anti-proliferative activity of TS extracts or gallic acid, was determined against EA.hy 926 and HUVECs by trypan blue exclusion method. Invasion, tube formation and chick chorioallantoic membrane assay were carried out to determine the in vitro and in vivo anti-angiogenic effects. RESULTS: Non-cytotoxic concentration of TS extracts (50-100µg/mL) and gallic acid (5µg/mL) inhibited the proliferation of VEGF-stimulated EA.hy 926 and HUVECs. Inhibitory effects of TS extracts and gallic acid on angiogenesis were assessed by VEGF-induced migration/invasion and capillary-like tube formation by EA.hy 926 and HUVECs. Additionally, gelatin zymography assays showed that TS extracts and gallic acid suppressed the activity of metalloproteinase (MMP)-9 and MMP-2 activated by VEGF. In vivo, TS extracts and gallic acid strongly suppressed neovessel formation in the chorioallantoic membrane of chick embryos. Flow cytometry analyses and Western blot demonstrated that treatment with TS extracts and gallic acid induced G(0)/G(1) arrest in VEGF-stimulated EA.hy 926 cells via a reduction in the amounts of cyclin D1, cyclin E, CDK4, hyperphosphorylated retinoblastoma protein (pRb), VEGFR-2, and eNOS. CONCLUSIONS: These results support an anti-angiogenic activity of Toona sinensis that may contribute critically to its cancer and inflammation chemopreventive potentials. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 134 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-03-08 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Endothelium, Vascular Drug Effects Meliaceae Chemistry Neovascularization, Pathologic Prevention & Control Plant Extracts Pharmacology Plant Leaves Vascular Endothelial Growth Factor A Antagonists & Inhibitors Cell Cycle Cell Line Cell Proliferation Cytology Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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