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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tang, Shu-Hong He, Rong-Rong Huang, Ting Wang, Cong-Zhi Cao, Yun-Feng Zhang, Yang Kurihara, Hiroshi |
| Description | Country affiliation: China Author Affiliation: Tang SH ( The Second Affiliated Hospital, Dalian Medical University, Dalian 116044, China.) |
| Abstract | AIM OF THE STUDY: The present study was conducted to investigate the effects of schisandra lignans extract (SLE) on stress-evoked hepatic metastases of mastocytoma P815 tumor cells, which was closely related with immune function. MATERIALS AND METHODS: The high-performance liquid chromatography (HPLC) fingerprint of SLE was recorded and the percentage composition of schisandra lignans was determined as 82.63%. The contributions of the immunomodulatory properties of SLE to the protective effects on stress-induced hepatic metastases were studied. RESULTS: Our results found that restraint stress significantly promoted hepatic metastases of P815 tumor cells. However, oral administration of SLE (100 and 200mg/kg/d, 14d) significantly reduced the number of metastatic colonies in liver of restrained mice. SLE was further found to be significantly improving T lymphocyte proportions and increasing cytotoxic T lymphocyte (CTL) activity of immunized spleen cells in stressed mice. CONCLUSION: These results indicated that the protective effects of SLE on hepatic metastases were related to its alleviation of the adverse effects of stressors for bio-homeostasis and immunoprotection. The obtained data provided evidences to elucidate the traditional use of Fructus schisandrae as a tonic or sedative. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 134 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-03-08 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Immobilization Lignans Pharmacology Liver Neoplasms, Experimental Secondary Mastocytoma Pathology Plant Extracts Schisandra Chemistry Stress, Physiological Animals Chromatography, High Pressure Liquid Female Immunology Prevention & Control Malondialdehyde Metabolism Mice Mice, Inbred Dba Spleen Cytology Drug Effects T-lymphocyte Subsets T-lymphocytes, Cytotoxic Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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