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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Neves, Camila Siqueira Gomes, Shaiany Sabrina Lopes Dos Santos, Tatianne Rosa de Almeida, Mariana Macedo de Souza, Yamara Oliveira Garcia, Raúl Marcel González Otoni, Wagner Campos Chedier, Luciana Moreira Viccini, Lyderson Facio de Campos, José Marcello Salabert |
| Description | Author Affiliation: Neves CS ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Genética e Biotecnologia, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: camila-neves@hotmail.com.); Gomes SS ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Genética e Biotecnologia, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: bioshaygomes@hotmail.com.); dos Santos TR ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Biologia Celular e Molecular, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: tatiannersantos@yahoo.com.br.); de Almeida MM ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Biologia Celular e Molecular, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: marimacedoa@hotmail.com.); de Souza YO ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Biologia Celular e Molecular, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: yamaraoliveirasouza@bol.com.br.); Garcia RM ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Biologia Celular e Molecular, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: raul.garcia@ufjf.edu.br.); Otoni WC ( Universidade Federal de Viçosa, Departamento de Biologia Vegetal, Laboratório de Cultura de Tecidos, CEP 36570-000, Viçosa, MG, Brazil. Electronic address: wcotoni@gmail.com.); Chedier LM ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Botânica, Laboratório de Fitoquímica, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: lmchedier@hotmail.com.); Viccini LF ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Genética e Biotecnologia, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: lyderson.viccini@gmail.com.); de Campos JM ( Universidade Federal de Juiz de Fora, Instituto de Ciências Biológicas, Departamento de Biologia, Laboratório de Genética e Biotecnologia, CEP 36036-900 Juiz de Fora, MG, Brazil. Electronic address: joseufjf@gmail.com.) |
| Abstract | ETHNAOPHARMACOLOGIAL RELEVANCE: In South America, the ß-ecdysone ecdysteroid has been found in species of the genus Pfaffia Mart. Due to the similar morphology of its roots to the Panax ginseng C. A. Mey. (Korean ginseng), some species of this genus has been known as Brazilian ginseng and have been used as tonic and aphrodisiac, as well as for the treatment of diabetes and rheumatism. AIM OF THE STUDY: Here we report a cytogenotoxic evaluation of ß-ecdysone (a natural ecdysteroid found in plants) in Rodent Bone Marrow Micronuclei and Allium cepa Assays. MATERIALS AND METHODS: Three ß-ecdysone (pure) concentrations (based in human therapeutic dosage) were used in the Micronucleus Assay. The animals were treated during two consecutive days. Micronucleated cells were counted in 2000 polychromatic erythrocytes per animal. For A. cepa L. Assay, one ß-ecdysone concentration was analyzed. The onions bulbs were exposed for 24h. RESULTS: The Micronucleus Assay showed genotoxic effects for all treatments, expressed by an increase of micronucleated cells. In A. cepa L. Assay, cell abnormalities associated to the malfunction/non-formation of mitotic spindle (aneugenic effect) and chromosomal bridges (clastogenic effect) were observed. CONCLUSIONS: The results indicate a cytogenotoxic activity of ß-ecdysone. Therefore, the popular use of Pfaffia and others species containing ß-ecdysone should be considered with caution. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 177 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-11 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Ecdysterone Toxicity Onions Drug Effects Animals Biological Assay Chromosome Aberrations Chemically Induced Chromosomes, Plant Dna Damage Male Micronuclei, Chromosome-defective Micronucleus Tests Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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