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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Feifei Ding, Yan Guo, Yingying Liu, Baoyue Kou, Zinong Xiao, Wei Zhu, Jingbo |
| Description | Author Affiliation: Xu F ( School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, PR China.); Ding Y ( School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, PR China); Guo Y ( School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, PR China.); Liu B ( School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, PR China.); Kou Z ( Instrumental analysis center, Dalian Polytechnic University, Dalian 116034, PR China.); Xiao W ( Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang 222001, PR China.); Zhu J ( School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, PR China) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium is a popular traditional herbal medicine worldwide that has long been used to relieve osteoporosis. The estrogenic properties of the herb are conferred by several phytoestrogens, such as flavonoids, lignans, and steroids. However, the poor understanding on the estrogen-like mechanism of Epimedium at the molecular and system levels limits the applications of this herb in osteoporosis treatment. MATERIALS AND METHODS: In this study, systems pharmacology was established to investigate the relationship between Epimedium and estrogen against osteoporosis by integrating active component screening, drug-likeness evaluation, herb feature mapping, target prediction and validation, and network analysis. RESULTS: A total of 77 active components that possessed similar structural features to estrogen as determined using herb feature mapping were selected from Epimedium by oral bioavailability prediction and drug-likeness evaluation. Twenty three osteoporosis-related targets were obtained from the active components of Epimedium as potential targets, 11 of which were common targets with estrogen. All osteoporosis-related targets were further mapped to compound-target and target-pathway networks. Results displayed that Epimedium can exert anti-osteoporosis effects by directly regulating the 11 estrogen-related targets and a set of target proteins on five estrogen-related pathways. CONCLUSION: This study explained the estrogen-like mechanism of Epimedium in preventing and treating osteoporosis, and provided a new standpoint for exploring the traditional herbal medicine against osteoporosis. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 177 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-11 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Epimedium Chemistry Estrogens Pharmacology Osteoporosis Drug Therapy Plant Extracts Systems Analysis Animals Databases, Factual Humans Molecular Structure Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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