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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Gabsik An, Duckgun Lee, Mi-Hwa Lee, Kyungjin Kim, Bumjung Suman, Chinannai Khanita Ham, Inhye Choi, Ho-Young |
| Description | Author Affiliation: Yang G ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea); An D ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Lee MH ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Lee K ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Kim B ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Suman CK ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Ham I ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea.); Choi HY ( Department of Herbology, College of Korean Medicine, Kyung Hee University, Republic of Korea. Electronic address: hychoi@khu.ac.kr.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Atopic dermatitis (AD) is a chronic and relapsing inflammatory condition characterized by pruritic and eczematous skin lesions that requires safe and effective pharmacological therapy. The bark of Acer tegmentosum Maxim trees has been used in Korean folk and traditional medicine to treat abscesses, surgical bleeding, liver diseases, and AD. AIM OF STUDY: To investigate the therapeutic effect of A. tegmentosum, on a mouse model of Dermatophagoides farinae (Df)-induced AD. METHODS: Development of AD-like skin lesions was induced by repetitive skin contact with barrier-disrupted backs of NC/Nga mice with Df body ointment, and the effects of A. tegmentosum were evaluated on the basis of histopathological skin assessment results, ear swelling, and cytokine production in the dorsal skin. The component of A. tegmentosum, salidroside, inhibited the production of TSLP in KCMH-1 cells, which indicated that its production could be pharmacologically regulated. RESULTS: Topical application of A. tegmentosum for 1 week after Df body ointment challenge significantly reduced ear swelling and improved dorsal skin lesions. Suppression of dermatitis by combined therapy was accompanied by a decrease in the skin level of Th2 cytokines, such as interleukin (IL)-4, IL-5 and IL-13, plasma levels of thymus and activation-regulated chemokine, and IgE. Induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also reduced in in vivo and in vitro by A. tegmentosum and salidroside. CONCLUSIONS: Our findings suggest that A. tegmentosum treatment has a significant therapeutic effect on Df-induced AD-like skin lesions on NC/Nga mice through inhibition of thymic stromal lymphopoietin and IgE via a mechanism that may inhibit Th2-mediated immune responses. These results suggest that A. tegmentosum and salidroside may be useful tools for the treatment of AD. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 177 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-11 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Acer Chemistry Antigens, Dermatophagoides Adverse Effects Dermatitis, Atopic Drug Therapy Plant Bark Animals Cell Line, Tumor Chemokine Ccl17 Genetics Metabolism Cytokines Immunoglobulin E Blood Male Mast Cells Mice Mice, Inbred Strains Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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