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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stone, Audrey J. Copp, Steven W. Kim, Joyce S. Kaufman, Marc P. |
| Description | Author Affiliation: Stone AJ ( Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania audrey.stone@austin.utexas.edu.); Copp SW ( Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.); Kim JS ( Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.); Kaufman MP ( Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.) |
| Abstract | In healthy humans, tests of the hypothesis that lactic acid, PGE2, or ATP plays a role in evoking the exercise pressor reflex proved controversial. The findings in humans resembled ours in decerebrate rats that individual blockade of the receptors to lactic acid, PGE2, and ATP had only small effects on the exercise pressor reflex provided that the muscles were freely perfused. This similarity between humans and rats prompted us to test the hypothesis that in rats with freely perfused muscles combined receptor blockade is required to attenuate the exercise pressor reflex. We first compared the reflex before and after injecting either PPADS (10 mg/kg), a P2X receptor antagonist, APETx2 (100 µg/kg), an activating acid-sensing ion channel 3 (ASIC) channel antagonist, or L161982 (2 µg/kg), an EP4 receptor antagonist, into the arterial supply of the hindlimb of decerebrated rats. We then examined the effects of combined blockade of P2X receptors, ASIC3 channels, and EP4 receptors on the exercise pressor reflex using the same doses, intra-arterial route, and time course of antagonist injections as those used for individual blockade. We found that neither PPADS (n = 5), APETx2 (n = 6), nor L161982 (n = 6) attenuated the reflex. In contrast, combined blockade of these receptors (n = 7) attenuated the peak (↓27%, P < 0.019) and integrated (↓48%, P < 0.004) pressor components of the reflex. Combined blockade injected intravenously had no effect on the reflex. We conclude that combined blockade of P2X receptors, ASIC3 channels, and EP4 receptors on the endings of thin fiber muscle afferents is required to attenuate the exercise pressor reflex in rats with freely perfused hindlimbs. |
| File Format | HTM / HTML |
| ISSN | 87507587 |
| e-ISSN | 15221601 |
| Journal | Journal of Applied Physiology |
| Issue Number | 11 |
| Volume Number | 119 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2015-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Acid Sensing Ion Channels Drug Effects Blood Pressure Muscle, Skeletal Physical Exertion Purinergic P2x Receptor Antagonists Pharmacology Receptors, Prostaglandin E, Ep4 Subtype Antagonists & Inhibitors Receptors, Purinergic P2x Animals Cnidarian Venoms Decerebrate State Hindlimb Blood Supply Neurons, Afferent Pyridoxal Phosphate Analogs & Derivatives Thiophenes Triazoles Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Sports Science |
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