NDLI: High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1 and glycolytic protein expression.

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High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1 and glycolytic protein expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abe, Takaaki Kitaoka, Yu Kikuchi, Dale Manjiro Takeda, Kohei Numata, Osamu Takemasa, Tohru
Description	Country affiliation: Japan Author Affiliation: Abe T ( Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Chiba, Japan); Kitaoka Y ( Department of Sports Sciences, The University of Tokyo, Meguro-ku, Tokyo, Japan); Kikuchi DM ( Department of Polar Science, Graduate University for Advanced Studies, Tachikawa, Tokyo, Japan); Takeda K ( Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan); Numata O ( Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.); Takemasa T ( Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan)
Abstract	It is known that repeated bouts of high-intensity interval training (HIIT) lead to enhanced levels of glycolysis, glycogenesis, and lactate transport proteins in skeletal muscle; however, little is known about the molecular mechanisms underlying these adaptations. To decipher the mechanism leading to improvement of skeletal muscle glycolytic capacity associated with HIIT, we examined the role of hypoxia-inducible factor-1 (Hif-1 ), the major transcription factor regulating the expression of genes related to anaerobic metabolism, in the adaptation to HIIT. First, we induced Hif-1 accumulation using ethyl 3,4-dihydroxybenzoate (EDHB) to assess the potential role of Hif-1 in skeletal muscle. Treatment with EDHB significantly increased the protein levels of Hif-1 in gastrocnemius muscles, accompanied by elevated expression of genes related to glycolysis, glycogenesis, and lactate transport. Daily administration of EDHB for 1 wk resulted in elevated glycolytic enzyme activity in gastrocnemius muscles. Second, we examined whether a single bout of HIIT could induce Hif-1 protein accumulation and subsequent increase in the expression of genes related to anaerobic metabolism in skeletal muscle. We observed that the protein levels of Hif-1 and expression of the target genes were elevated 3 h after an acute bout of HIIT in gastrocnemius muscles. Last, we examined the effects of long-term HIIT. We found that long-term HIIT increased the basal levels of Hif-1 as well as the glycolytic capacity in gastrocnemius muscles. Our results suggest that Hif-1 is a key regulator in the metabolic adaptation to high-intensity training.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	11
Volume Number	119
Language	English
Publisher	American Physiological Society
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Adaptation, Physiological Physiology Glycolysis Hypoxia-inducible Factor 1, Alpha Subunit Biosynthesis Muscle, Skeletal Physical Conditioning, Animal Anaerobiosis Genetics Animals Gene Expression Regulation Glycogen Hydroxybenzoates Pharmacology Lactic Acid Metabolism Mice Mice, Inbred Icr Enzymology Isolation & Purification
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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