NDLI: Neuropeptide Y Incorporated Into PVAX Nanoparticle Improves Functional Blood Flow In A Murine Model Of Hind Limb Ischemia.

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Neuropeptide Y Incorporated Into PVAX Nanoparticle Improves Functional Blood Flow In A Murine Model Of Hind Limb Ischemia.

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Neuropeptide Y Incorporated Into PVAX Nanoparticle Improves Functional Blood Flow In A Murine Model Of Hind Limb Ischemia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eshun, Derek Saraf, Rabya Bae, Soochan Jeganathan, Jelliffe Mahmood, Feroze Dilmen, Serkan Ke, Qingen Lee, Dongwon Kang, Peter M. Matyal, Robina
Description	Author Affiliation: Eshun D ( Beth Israel Deaconess Medical Center, Harvard Medical School.); Saraf R ( Beth Israel Deaconess Medical Center, Harvard Medical School.); Bae S ( Beth Israel Deaconess Medical Center.); Jeganathan J ( Beth Israel Deaconess Medical Center, Harvard Medical School.); Mahmood F ( Harvard Medical School, BIMC.); Dilmen S ( Beth Israel Deaconess Medical Center, Harvard Medical School.); Ke Q ( Beth Israel Deaconess Medical Center and Harvard Medical School.); Lee D ( Chonbuk National University.); Kang PM ( Beth Israel Deaconess Medical Center.); Matyal R ( Beth Israel Deaconess Medical Center, Harvard Medical School rmatyal1@bidmc.harvard.edu.)
Abstract	We generated a novel nanoparticle called PVAX, which has intrinsic anti-apoptotic and anti-inflammatory properties. This nanoparticle was loaded with Neuropeptide Y , an angiogenic neuro-hormone that plays a central role in angiogenesis. Subsequently, we investigated whether PVAX-NPY could act as a therapeutic agent and induce angiogenesis and vascular remodeling in a murine model of hind limb ischemia. Adult C57BL/J6 mice (n=40) were assigned to treatment groups: Control, Ischemia PBS, Ischemia PVAX, Ischemia NPY , and Ischemia PVAX-NPY Ischemia was induced by ligation of the femoral artery in all groups except Control and given relevant treatments (PBS, PVAX, NPY , and PVAX-NPY ). Blood flow was quantified using laser Doppler imaging. On days 3 and 14 post-treatment, mice were euthanized to harvest gastrocnemius muscle for immunohistochemistry and immunoblotting. Blood flow was significantly improved in the PVAX-NPY group after 14 days. Western blot showed an increase in angiogenic factors VEGF-R2 and PDGF-ß (p=0.0035 and p=0.031, respectively) and anti-apoptotic marker Bcl-2 in the PVAX-NPY group as compared to Ischemia PBS group (p=0.023). Pro-apoptotic marker Smad5 was significantly decreased in the PVAX-NPY group as compared to the Ischemia PBS group (p=0.028). Furthermore, Y2 receptors were visualized in endothelial cells of newly formed arteries in the PVAX-NPY group. In conclusion, we were able to show that PVAX-NPY can induce angiogenesis and arteriogenesis as well as improve functional blood flow in a murine model of hind limb ischemia.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2017-03-16
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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