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Active shortening protects against stretch-induced force deficits in human skeletal muscle.

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Active shortening protects against stretch-induced force deficits in human skeletal muscle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Saripalli, Anjali L. Sugg, Kristoffer B. Mendias, Christopher L. Brooks, Susan V. Claflin, Dennis R.
Description	Author Affiliation: Saripalli AL ( University of Michigan.); Sugg KB ( University of Michigan.); Mendias CL ( University of Michigan.); Brooks SV ( University of Michigan.); Claflin DR ( University of Michigan claflin@umich.edu.)
Abstract	Skeletal muscle contraction results from molecular interactions of myosin 'crossbridges' with adjacent actin filament binding sites. The binding of myosin to actin can be 'weak' or 'strong', and only strong binding states contribute to force production. During active shortening, the number of strongly-bound crossbridges declines with increasing shortening velocity. Forcibly stretching a muscle that is actively shortening at high velocity results in no apparent negative consequences whereas stretch of an isometrically (fixed-length) contracting muscle causes ultrastructural damage and a decline in force-generating capability. Our working hypothesis is that stretch-induced damage is uniquely attributable to the population of crossbridges that are strongly-bound. We tested the hypothesis that stretch-induced force deficits decline as the prevailing shortening velocity is increased. Experiments were performed on permeabilized segments of individual skeletal muscle fibers obtained from human subjects. Fibers were maximally activated and either allowed to generate maximum isometric force (F ), or to shorten at velocities that resulted in force maintenance of ≈50% F or ≈2% Fo. For each test condition, a rapid stretch equivalent to 0.1 x optimal fiber length was applied. Relative to pre-stretch F , force deficits resulting from stretches applied during force maintenance of 100%, ≈50%, and ≈2% F were 23.2 ± 8.6%, 7.8 ± 4.2% and 0.3 ± 3.3%, respectively (mean ± SD, n=20). We conclude that stretch-induced damage declines with increasing shortening velocity, consistent with the working hypothesis that the fraction of strongly-bound crossbridges is a causative factor in the susceptibility of skeletal muscle to stretch-induced damage.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2017-02-23
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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