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Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice.

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Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chatel, Benjamin Messonnier, Laurent André Hourdé, Christophe Vilmen, Christophe Bernard, Monique Bendahan, David
Description	Author Affiliation: Chatel B ( Aix-Marseille Univ benjamin.chatel@live.fr.); Messonnier LA ( Université Savoie Mont Blanc.); Hourdé C ( Université Savoie Mont Blanc.); Vilmen C ( Aix-Marseille Université, CNRS, CRMBM UMR 7339.); Bernard M ( Aix-Marseille Université, CNRS, CRMBM UMR 7339.); Bendahan D ( Aix-Marseille University, CNRS.)
Abstract	Sickle cell disease (SCD) is associated with an impaired oxygen delivery to skeletal muscle that could alter ATP production processes. The present study aimed to determine the effects of sickle hemoglobin (HbS) on muscle pH homeostasis in response to exercise in homozygous (HbSS, n = 9) and heterozygous (HbAS, n = 10) SCD (Townes) mice in comparison to control (HbAA, n = 10) littermates. Magnetic resonance spectroscopy of phosphorus 31 enabled to measure intramuscular pH (pH ) and phosphocreatine (PCr) concentration during rest-stimulation-recovery protocols at two different intensities. Maximal activity of some enzymes involved in muscle energetics and content of proteins involved in pH regulation were also investigated. HbSS mice presented a more pronounced exercise-induced intramuscular acidosis, whatever the intensity of exercise. Moreover, the depletion of PCr was also exacerbated in HbSS mice in response to intense exercise as compared to both HbAA and HbAS mice (p < 0.01). While no difference was observed concerning proteins involved in muscle pH regulation, the activity of enolase (a glycolytic enzyme) was higher in both HbSS and HbAS mice as compared to controls (p < 0.05). Interestingly, HbAS mice presented also metabolic impairments as compared to their control counterparts. This study has identified for the first time an exacerbated exercise-induced intramuscular acidosis in SCD mice.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2017-03-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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