NDLI: Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.

Please wait, while we are loading the content...

Year: 2017 Volume: 139

Year: 2016 Volume: 138

Year: 2016 Volume: 137

Year: 2015 Volume: 136

Year: 2015 Volume: 135

Year: 2014 Volume: 134

Year: 2014 Volume: 133

Year: 2013 Volume: 132

Year: 2013 Volume: 131

Year: 2013 Volume: 131 Issue: 6

Year: 2013 Volume: 131 Issue: 5

Year: 2013 Volume: 131 Issue: 4

Year: 2013 Volume: 131 Issue: 3

Year: 2013 Volume: 131 Issue: 2

Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking.

Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.

Disseminated Mycobacterium genavense infection after immunosuppressive therapy shows underlying new composite heterozygous mutations of ß1 subunit of IL-12 receptor gene.

Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease.

Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation.

Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome.

The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm).

Relation between objective measures of atopy and myocardial infarction in the United States.

Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent mouse model of allergic asthma

Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.

Undiagnosed submucous cleft palate interfering with inhalation therapy and a solution.

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma.

Prophylactic therapy in children with hereditary angioedema.

Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways.

Pharmacoeconomic advantages of subcutaneous versus intravenous immunoglobulin treatment in a Canadian pediatric center.

Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.

Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes.

Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)2.

Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia.

Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients.

TGF-ß1 polymorphisms and asthma severity, airway inflammation, and remodeling.

IL-22 suppresses IFN-Î³-mediated lung inflammation in asthmatic patients.

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.

Classification of primary immunodeficiencies: need for a revised approach?

Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice.

Reliability, validity, and responsiveness of the Rhinitis Control Assessment Test in patients with rhinitis.

TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes.

Î¶ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance.

Mental health comorbidity in patients with atopic dermatitis.

Pulmonary 3He magnetic resonance imaging of childhood asthma.

Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal -toxin-induced keratinocyte death.

Variable yield of allergy patch testing in children with eosinophilic esophagitis.

Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma.

Reply: To PMID 22867695.

Asthma-associated differences in microbial composition of induced sputum.

Residual genomic signature of atopic dermatitis despite clinical resolution with narrow-band UVB.

Clara cell 10-kDa protein inhibits $T_{H}17$ responses through modulating dendritic cells in the setting of allergic rhinitis

Reply: To PMID 22554708.

Genetic variation in the Toll-like receptor signaling pathway is associated with childhood asthma.

The correct usage of the term 'low-birth-weight infant'.

Reply: To PMID 22935624.

Systemic mastocytosis as a risk factor for severe Hymenoptera sting-induced anaphylaxis.

Reply: To PMID 22336082.

Tick-borne encephalitis virus vaccine as additional alternative neoantigen for the clinical immunologist's toolbox.

The cutaneous innate immune response in patients with atopic dermatitis.

The multifunctional role of filaggrin in allergic skin disease.

Atopic dermatitis: a practice parameter update 2012.

Primary immunodeficiencies: a rapidly evolving story.

Vitamin D in allergic disease: shedding light on a complex problem.

Asthma and lung structure on computed tomography: the Multi-Ethnic Study of Atherosclerosis Lung Study.

Insights into pediatric asthma with hyperpolarized magnetic resonance imaging of the lung.

Rhinovirus has the unique ability to directly activate human T cells in vitro.

Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitis.

Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.

Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.

IgE cross-linking critically impairs human monocyte function by blocking phagocytosis.

Combined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections.

Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR-10) protein allergy resolved after immunotherapy.

Somatic D816V KIT mutation in a case of adult-onset familial mastocytosis.

Laboratory evaluation for T-cell dysfunction.

Year: 2013 Volume: 131 Issue: 1

Year: 2012 Volume: 130

Year: 2012 Volume: 129

Year: 2011 Volume: 128

Year: 2011 Volume: 127

Year: 2010 Volume: 126

Year: 2010 Volume: 125

Year: 2009 Volume: 124

Year: 2009 Volume: 123

Year: 2008 Volume: 122

Year: 2008 Volume: 121

Year: 2007 Volume: 120

Year: 2007 Volume: 119

Year: 2006 Volume: 118

Year: 2006 Volume: 117

Year: 2005 Volume: 116

Year: 2005 Volume: 115

Year: 2004 Volume: 113

Year: 2001 Volume: 108

Year: 2000 Volume: 106

Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guan, Weijie Zheng, Jinping Gao, Yi Jiang, Caiyu Xie, Yanqing An, Jiaying Yu, Xinxin Liu, Wenting Zhong, Nanshan
Description	Country affiliation: China Author Affiliation: Guan W ( State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.)
Abstract	BACKGROUND: Both leukotriene D(4) (LTD(4)) and methacholine bronchial provocation tests are measurements of airway responsiveness; however, their correlation and distinction remain unexplored. OBJECTIVES: We sought to compare the 2 tests and classify leukotriene-responsiveness subtypes in asthmatic patients. METHODS: In this randomized cross-over study we enrolled healthy subjects and asthmatic patients with different control statuses. All subjects underwent both tests with a 2- to 14-day interval. Distribution and correlation of cumulative doses inducing a 20% decrease in FEV(1), LTD(4)/methacholine potency ratio, diagnostic value, and adverse events were recorded and analyzed. Asthmatic patients with a lower cumulative dose for LTD(4) and a higher leukotriene/methacholine potency ratio than geometric means were regarded as leukotriene responsive. RESULTS: Twenty patients with uncontrolled, 22 with partly controlled, and 20 with controlled asthma and 21 healthy subjects were enrolled. Geometric means of cumulative doses for LTD(4) and methacholine (0.272 nmol vs 0.945 µmol) were lowest in patients with uncontrolled asthma, followed by those with partly controlled (0.387 nmol vs 1.933 µmol) and controlled (1.484 nmol vs 3.946 µmol) asthma. The average potency ratio was highest in those with partly controlled asthma (5000.2), followed by those with uncontrolled (3477.7) and controlled (2702.6) asthma. Eighteen leukotriene-responsive asthmatic patients (29.03%) with a cumulative dose of LTD(4) of 0.533 nmol or less and a potency ratio of 3647 or greater were identified. Adverse events, including tachypnea and chest tightness, were similar and mild. No serious adverse event was reported. CONCLUSION: Diagnostic value and safety were ideal in both tests. The combination of cumulative dose for LTD(4) and potency ratio might be useful to identify leukotriene-responsive asthmatic patients.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	131
Language	English
Publisher	Elsevier
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Asthma Diagnosis Bronchi Drug Effects Bronchial Provocation Tests Leukotriene D4 Methacholine Chloride Administration, Inhalation Case-control Studies Cross-over Studies Administration & Dosage Adverse Effects Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in