NDLI: B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.

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Year: 2008 Volume: 154 Issue: 1

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B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cardoso, C. R. Provinciatto, P. R. Godoi, D. F. Vieira, T. S. Ferreira, B. R. Teixeira, G. Rossi, M. A. Cunha, F. Q. Silva, J. S.
Description	Country affiliation: Brazil Author Affiliation: Cardoso CR ( Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeiráo Preto, SP, Brazil.)
Abstract	Food enteropathies involve uncontrolled or hypersensitivity reactions to ingested nutrients and may result in IgE and T-helper type 2 (Th2) responses as in food allergy. However, the precise role of B cells in the development of food enteropathies remains uncertain. In this work, we used B cell-deficient mice (B KO) and a model of peanut sensitization to examine the involvement of B lymphocytes in the pathogenesis of food allergy. Results showed that priming of wild-type (WT) mice with peanut proteins induced specific IgG1 and IgE responses in serum, with edema, tissue destruction, epithelial exulceration and inflammatory infiltrate in the gut of sensitized and challenged (S + Peanut) WT animals. In contrast, there was no sera immunoglobulin detection and absence of tissue destruction in the gut of B KO mice, which presented moderate inflammatory infiltrate and villous enlargement after peanut challenge. These animals presented marked decrease in IL-4 and TNF-alpha and high levels of IL-10, TGF-beta, IL-12p40 and IFN-gamma mRNA in the gut. Moreover, the expression of CCL5, CCL11 and CXCL1 was reduced in the gut of B KO mice, in contrast to elevated messages of CCL2 or similar detection of Th1-related chemokines in S + Peanut WT mice. Finally, we provided evidence that B cells are necessary to the development of food-related enteropathies and induction of gut inflammation during allergic reactions to food.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/j.1365-2249.2008.03748.x
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	154
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology B-lymphocytes Immunology Enteritis Peanut Hypersensitivity Allergens Animals Arachis Hypogaea Chemokines Metabolism Cytokines Pathology Immunoglobulins Biosynthesis Jejunum Ultrastructure Mice Mice, Inbred C57bl Mice, Knockout Th2 Cells Vegetable Proteins Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.

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