NDLI: Time of decline in sexual function after external beam radiotherapy for prostate cancer.

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Time of decline in sexual function after external beam radiotherapy for prostate cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siglin, Joshua Kubicek, Gregory J. Leiby, Benjamin Valicenti, Richard K.
Description	Country affiliation: United States Author Affiliation: Siglin J ( Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA.)
Abstract	PURPOSE: Erectile dysfunction is one of the most concerning toxicities for patients in the treatment of prostate cancer. The inconsistent evaluation of sexual function (SF) and limited follow-up data have necessitated additional study to clarify the rate and timing of erectile dysfunction after external beam radiotherapy (EBRT) for prostate cancer. METHODS AND MATERIALS: A total of 143 men completed baseline data on SF before treatment and at the subsequent follow-up visits. A total of 1187 validated SF inventories were analyzed from the study participants. Multiple domains of SF (sex drive, erectile function, ejaculatory function, and overall satisfaction) were analyzed for < or =8 years of follow-up. RESULTS: The median follow-up was 4.03 years. The strongest predictor of SF after EBRT was SF before treatment. For all domains of SF, the only statistically significant decrease in function occurred in the first 24 months after EBRT. SF stabilized 2 years after treatment completion, with no statistically significant change in any area of SF >2 years after the end of EBRT. CONCLUSION: These data suggest that SF does not have a continuous decline after EBRT. Instead, SF decreases maximally within the first 24 months after EBRT, with no significant changes thereafter.
File Format	HTM / HTML
ISSN	03603016
Issue Number	1
Volume Number	76
e-ISSN	1879355X
Journal	International Journal of Radiation OncologyastBiologyastPhysics
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Erectile Dysfunction Etiology Patient Satisfaction Penile Erection Radiation Effects Prostatic Neoplasms Radiotherapy Aged Aged, 80 And Over Ejaculation Physiology Physiopathology Follow-up Studies Humans Libido Male Middle Aged Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology

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