NDLI: Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.

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Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.

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Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oh, Jee-Sun Kim, Jae-Jin Byun, Ju-Yeon Kim, In-Ah
Description	Author Affiliation: Oh JS ( Medical Science Research Institute, Seoul National University Bundang Hospital, Seongnamsi, Korea.)
Abstract	PURPOSE: To evaluate the potential of targeting Lin28-let7 microRNA regulatory network for overcoming the radioresistance of cancer cells having activated K-Ras signaling. METHODS AND MATERIALS: A549 lung carcinoma cells and ASPC1 pancreatic cancer cells possessing K-RAS mutation were transfected with pre-let7a microRNA or Lin28 siRNA, respectively. Clonogenic assay, quantitative reverse transcription polymerase chain reaction, and Western analysis were performed. The effects of Lin28 on SQ20B cells having wild-type K-RAS, and a normal fibroblast were also assessed. RESULTS: The overexpression of let-7a decreased expression of K-Ras and radiosensitized A549 cells. Inhibition of Lin28, a repressor of let-7, attenuated K-Ras expression and radiosensitized A549 and ASPC1 cells. Neither SQ20B cells expressing wild-type K-RAS nor HDF, the normal human fibroblasts, were radiosensitized by this approach. CONCLUSIONS: The Lin28-let7 regulatory network may be a potentially useful therapeutic target for overcoming the radioresistance of human cancers having activated K-Ras signaling.
File Format	HTM / HTML
ISSN	03603016
Issue Number	1
Volume Number	76
e-ISSN	1879355X
Journal	International Journal of Radiation OncologyastBiologyastPhysics
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Genes, Ras Genetics Micrornas Metabolism Rna, Small Interfering Rna-binding Proteins Antagonists & Inhibitors Radiation Tolerance Blotting, Western Cell Line, Tumor Radiation Effects Fibroblasts Gene Expression Humans Lung Neoplasms Radiotherapy Mutation Pancreatic Neoplasms Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Transfection Methods Tumor Stem Cell Assay Ras Proteins Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology

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