NDLI: Sexual function in males after radiotherapy for rectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bruheim, Kjersti Guren, Marianne G. Dahl, Alv A. Skovlund, Eva Balteskard, Lise Carlsen, Erik Fosså, Sophie D. Tveit, Kjell Magne
Spatial Coverage	Norway
Description	Country affiliation: Norway Author Affiliation: Bruheim K ( Oslo University Hospital, Ullevål Cancer Centre, 0407 Oslo, Norway. Kjersti.bruheim@medisin.uio.no)
Abstract	PURPOSE: Knowledge of sexual problems after pre- or postoperative radiotherapy (RT) with 50 Gy for rectal cancer is limited. In this study, we aimed to compare self-rated sexual functioning in irradiated (RT+) and nonirradiated (RT-) male patients at least 2 years after surgery for rectal cancer. METHODS AND MATERIALS: Patients diagnosed with rectal cancer from 1993 to 2003 were identified from the Norwegian Rectal Cancer Registry. Male patients without recurrence at the time of the study. The International Index of Erectile Function, a self-rated instrument, was used to assess sexual functioning, and serum levels of serum testosterone were measured. RESULTS: Questionnaires were returned from 241 patients a median of 4.5 years after surgery. The median age was 67 years at survey. RT+ patients (n = 108) had significantly poorer scores for erectile function, orgasmic function, intercourse satisfaction, and overall satisfaction with sex life compared with RT- patients (n = 133). In multiple age-adjusted analysis, the odds ratio for moderate-severe erectile dysfunction in RT+ patients was 7.3 compared with RT- patients (p <0.001). Furthermore, erectile dysfunction of this degree was associated with low serum testosterone (p = 0.01). CONCLUSION: RT for rectal cancer is associated with significant long-term effects on sexual function in males.
File Format	HTM / HTML
ISSN	03603016
Issue Number	4
Volume Number	76
e-ISSN	1879355X
Journal	International Journal of Radiation OncologyastBiologyastPhysics
Language	English
Publisher	Elsevier
Publisher Date	2010-03-15
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Erectile Dysfunction Etiology Penile Erection Radiation Effects Rectal Neoplasms Radiotherapy Aged Chi-square Distribution Dose Fractionation Blood Physiopathology Humans Male Middle Aged Norway Physiology Adverse Effects Drug Therapy Surgery Statistics, Nonparametric Questionnaires Testosterone Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology

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