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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, Jinli Zhang, Junan Zhou, Sumin Hubbs, Jessica L. Foltz, Rodney J. Hollis, Donna R. Light, Kim L. Wong, Terence Z. Kelsey, Christopher R. Marks, Lawrence B. |
| Description | Country affiliation: United States Author Affiliation: Ma J ( Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27599-7512, USA.) |
| Abstract | PURPOSE: To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors. METHODS AND MATERIALS: Between 1991 and 2004, 118 patients with interpretable pre- and post-radiation therapy (RT) chest computed tomography (CT) scans were evaluated. Changes in regional lung density were related to regional dose to define a dose-response curve (DRC) for RT-induced lung injury using three-dimensional planning tools and image fusion. Multiple post-RT follow-up CT scans were evaluated by fitting linear-quadratic models of density changes on dose with time as the covariate. Various patient- and treatment-related factors were examined as well. RESULTS: There was a dose-dependent increase in regional lung density at nearly all post-RT follow-up intervals. The population volume-weighted changes evolved over the initial 6-month period after RT and reached a plateau thereafter (p < 0.001). On univariate analysis, patient age greater than 65 years (p = 0.003) and/or the use of pre-RT surgery (p < 0.001) were associated with significantly greater changes in CT density at both 6 and 12 months after RT, but the magnitude of this effect was modest. CONCLUSIONS: There appears to be a temporal nature for the dose-dependent increases in lung density. Nondosimetric clinical factors tend to have no, or a modest, impact on these changes. |
| File Format | HTM / HTML |
| ISSN | 03603016 |
| Issue Number | 1 |
| Volume Number | 76 |
| e-ISSN | 1879355X |
| Journal | International Journal of Radiation OncologyastBiologyastPhysics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Radiology Lung Radiation Effects Radiation Injuries Adult Aged Aged, 80 And Over Algorithms Analysis Of Variance Breast Neoplasms Radiotherapy Dose-response Relationship, Radiation Female Follow-up Studies Humans Linear Models Lung Neoplasms Lymphoma Male Middle Aged Prospective Studies Radiotherapy Planning, Computer-assisted Tomography, X-ray Computed Young Adult Journal Article Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology |
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