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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bagheri, Zeinab Ranjbar, Bijan Latifi, Hamid Zibaii, Mohammad Ismail Moghadam, Tahereh Tohidi Azizi, Azade |
| Description | Country affiliation: Iran Author Affiliation: Bagheri Z ( Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.); Ranjbar B ( Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran); Latifi H ( Laser and Plasma Research Institute, Shahid Beheshti University, Evin, Tehran, Iran. Electronic address: latifi@sbu.ac.ir.); Zibaii MI ( Laser and Plasma Research Institute, Shahid Beheshti University, Evin, Tehran, Iran.); Moghadam TT ( Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.); Azizi A ( Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.) |
| Abstract | G-quadruplexes are supramolecular structures of G-rich nucleic acid, formed by non-canonical base pairing in the presence of specific environmental inducers. These structures have been vastly considered in diagnostic and therapeutic applications. However, detailed information on structure, optical properties and thermal stability of G-quadruplex potent oligonucleotides is scarce. Herein, optical properties and thermodynamic stability of AS1411 quadruplex is reported for various concentrations of potassium and lead ions. Circular dichroism showed that AS1411 ss-DNA folds into parallel conformation in the presence of metal ions and molecular crowding condition. UV-vis spectroscopy indicated formation of quadruplex and fluorescent spectroscopy revealed intercalation of PicoGreen in its structure, with enhancement of emission intensity upon increment of metal ion concentration. This investigation also proposes high-throughput and reliable analysis of AS1411 quadruplex's thermal stability by real-time PCR technique, which can be further applied for other quadruplex structures. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 72 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Dna Chemistry G-quadruplexes Circular Dichroism Metabolism Dna, Catalytic Oligonucleotides Thermodynamics Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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