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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shah, Asima Ahmad, Mudasir Ashwar, Bilal Ahmad Gani, Adil Masoodi, Farooq Ahmad Wani, Idrees Ahmed Wani, Sajad Mohd Gani, Asir |
| Description | Country affiliation: India Author Affiliation: Shah A ( Department of Food Science and Technology, University of Kashmir, India.); Ahmad M ( Department of Food Science and Technology, University of Kashmir, India.); Ashwar BA ( Department of Food Science and Technology, University of Kashmir, India.); Gani A ( Department of Food Science and Technology, University of Kashmir, India. Electronic address: adil.gani@gmail.com.); Masoodi FA ( Department of Food Science and Technology, University of Kashmir, India.); Wani IA ( Department of Food Science and Technology, University of Kashmir, India.); Wani SM ( Department of Food Science and Technology, University of Kashmir, India.); Gani A ( Department of Food Technology Guru Nanak Dev University, Amritsar, Punjab, India.) |
| Abstract | This paper reports the characterization and potential antioxidant activity of ß-D-glucan isolated from barley treated with γ-rays. The ß-D-glucan was irradiated with 0, 2, 4 and 8 kGy by gamma ray. The samples were characterized by Fourier transform-infrared spectroscopy, gel permeation chromatography (GPC) and quantitative estimation by Megazyme ß-D-glucan assay kit. The average molecular weight of non-irradiated ß-D-glucan was 177 kDa that decreased to 79 kDa at 8 kGy. Antioxidant activity was evaluated by five complementary assays including DPPH, lipid peroxidation, reducing power, metal chelating ability and oxidative DNA damage assays. Further, the antiproliferative potential of irradiated ß-D-glucan was tested against three human cancer cell lines including Colo-205, T47D and MCF7 using MTT assay. Irradiated ß-D-glucan exhibited dose dependent cancer cell growth inhibition. In conclusion, the present study demonstrates that irradiation leads to the formation of low molecular weight ß-D-glucan with enhanced antioxidant and antiproliferative activities. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 72 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Dietary Supplements Analysis Gamma Rays Hordeum Chemistry Beta-glucans Pharmacology Antioxidants Biphenyl Compounds Cell Line, Tumor Cell Proliferation Drug Effects Radiation Effects Dna Damage Free Radical Scavengers Humans Iron Chelating Agents Lipid Peroxidation Molecular Weight Oxidation-reduction Picrates Spectroscopy, Fourier Transform Infrared Viscosity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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