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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | O'Connor, Naphtali A. Abugharbieh, Ahmad Yasmeen, Farzana Buabeng, Emmanuel Mathew, Steve Samaroo, Diana Cheng, Hai-Ping |
| Description | Author Affiliation: O'Connor NA ( Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468, United States. Electronic address: naphtali.oconnor@lehman.cuny.edu.); Abugharbieh A ( Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468, United States.); Yasmeen F ( Department of Biology, Lehman College of the City University of New York, Bronx, NY 10468, United States.); Buabeng E ( Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468, United States.); Mathew S ( Department of Chemistry, Lehman College of the City University of New York, Bronx, NY 10468, United States.); Samaroo D ( Department of Chemistry, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, United States.); Cheng HP ( Department of Biology, Lehman College of the City University of New York, Bronx, NY 10468, United States.) |
| Abstract | A facile modular approach to rapidly prepare pH-responsive hydrogels by crosslinking polysaccharides with polyamines is demonstrated. Hydrogels are prepared by first reacting the less reactive polysaccharides with the cross-linker epichlorohydrin and completed by the addition of polyamines. The crosslinking of polysaccharides with polyamines provides a facile method for incorporating functionality into polysaccharide based hydrogels. This process is demonstrated with the polysaccharides dextran, pullulan and carboxymethyl cellulose and with the polyamines polyallylamine and polyethylene imine. The hydrogels were characterized by FTIR and swelling studies, which showed pH-dependent swelling due to the presence of the polyamine. The hydrogels can also be tailored by varying the mass ratio between the polysaccharide and polyamine. Absorption studies of organic analytes showed the polyamine content affecting the uptake of a charged substrate (methylene blue) and no effect on a neutral substrate (6-methyl coumarin). This synthetic method was also used to prepare hydrogels with antibacterial activity against E. coli and S. aureus by utilizing an amphiphilic polyallylamine. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 72 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Anti-bacterial Agents Pharmacology Cross-linking Reagents Dextrans Hydrogels Polyamines Absorption, Physicochemical Chemical Synthesis Chemistry Escherichia Coli Drug Effects Microbial Sensitivity Tests Spectroscopy, Fourier Transform Infrared Staphylococcus Aureus Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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