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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bing, So Jin Ha, Danbee Kim, Min Ju Park, Eunjin Ahn, Ginnae Kim, Dae Seung Ko, Ryeo Kyeong Park, Jae Woo Lee, Nam Ho Jee, Youngheun |
| Description | Country affiliation: South Korea Author Affiliation: Bing SJ ( Department of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University, Ara-dong 1, Jeju 690-756, South Korea.) |
| Abstract | Gamma ray irradiation triggers DNA damage and apoptosis of proliferating stem cells and peripheral immune cells, resulting in the destruction of intestinal crypts and lymphoid system. Geraniin is a natural compound extracts from an aquatic plant Nymphaea tetragona and possesses good antioxidant property. In this study, we demonstrate that geraniin rescues radiosensitive splenocytes and jejunal crypt cells from radiation-induced DNA damage and apoptosis. Isolated splenocytes from C57BL/6 mice treated with geraniin were protected against radiation injury of 2 Gy irradiation through the enhancement of the proliferation and attenuation of DNA damage. Also, geraniin inhibited apoptosis in radiosensitive splenocytes by reducing the expression level and immunoreactivity of proapoptotic p53 and Bax and increasing those of anti-apoptotic Bcl-2. In mice exposed to radiation, geraniin treatment protected splenocytes and intestinal crypt cells from radiation-induced cell death. Our results suggest that geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Therefore, geraniin can be a radioprotective agent against γ-irradiation exposure. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 57 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Apoptosis Drug Effects Dna Damage Glucosides Pharmacology Hydrolyzable Tannins Radiation-protective Agents Animals Radiation Effects Cell Proliferation Cells, Cultured Gamma Rays Genes, P53 Administration & Dosage Toxicity Injections, Intraperitoneal Intestine, Small Pathology Jejunum Cytology Mice Mice, Inbred C57bl Nymphaea Chemistry Proto-oncogene Proteins C-bcl-2 Metabolism Radiation, Ionizing Spleen Toxicity Tests, Acute Whole-body Irradiation Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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