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Preface

Electric-field control of the activity of the graphene-based catalyst

First-principles investigation of the effects of B impurities on the mechanical properties of NiAl intermetallics

The effect of boron on the electronic structure of dislocation in NiAl

Energy studies of precipitation sequence in Ni$_{75}$Al$_{10}$Cr$_{15}$ alloy based on the phase field theory

First-principles study of He point-defects in HCP rare-earth metals

The first-principle study on the equation of state of HMX under high pressure

Atomistic simulation of dynamical and defect properties of multiferroic hexagonal YMnO$_{3}$

Quantum conductance of armchair carbon nanocoils: roles of geometry effects

Diffusion of Pt dimers on a Wulff polyhedral surface

Three-dimensional microstructure simulation of Ni-based superalloy investment castings

Phase-field modeling of void evolution and swelling in materials under irradiation

Investigation of morphology selection for CBr$_{4}$-C$_{2}$Cl$_{6}$ alloy in three dimensions with multi-phase field method

Modelling of grain boundary impurity segregation during high temperature plastic deformation

Prediction of thermal conductivity of polymer-based composites by using support vector regression

Theoretical study of the electronic ground states and low-lying singlet excited states of thiophene-based spirofluorenes

3D finite element simulation of explosive welding of three-layer plates

Size and composition dependence of melting temperature of binary nanoparticles

Dendritic growth and solute trapping in rapidly solidified Cu-based alloys

Effects of source opacity and expansion on two-pion Bose-Einstein correlations

BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation

Probe stiffness regulates receptor-ligand bond lifetime under force

Realization of superposition and entanglement of coherent and squeezed states in circuit quantum electrodynamics

Experimental implementation of a fixed-point duality quantum search algorithm in the nuclear magnetic resonance quantum system

Robust quantum secure direct communication with a quantum one-time pad over a collective-noise channel

Thermo-hyperelastic models for nanostructured materials

Electromechanical cracking in ferroelectrics driven by large scale domain switching

An experimental investigation into electromyography, constitutive relationship and morphology of crucian carp for biomechanical “digital fish”

HF SAR image cross-correlation technique for high accuracy orbit positioning

Evolution of the vortex structures and turbulent spots at the late-stage of transitional boundary layers

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BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation

Content Provider	Springer Nature Link
Author	Wang, YanLing Wang, Bing Zhang, Hong Li, Ning Tanaka, Kaoru Zhou, Xin Chen, RuPing Zhang, Xin
Copyright Year	2011
Abstract	BRCA1 has been proposed to be tightly linked to the resistance of tumor cells to ionizing radiation. The pathway leading to this phenomenon is not yet clear. In this work, we investigated the role of BRCA1 in the apoptosis regulation in response to carbon ion irradiation. We utilized three different cancer cell lines with various states for BRCA1 and p53 to identify the relationship between endogenous BRCA1 and the apoptosis-related genes, and determine whether p53 function would affect the role of BRCA1 in apoptosis regulation. By Western blot analysis, we found that Bax expressions were not significantly changed after irradiation in all of three cell lines. However, Bcl-2 expression showed an up-regulation by endogenous BRCA1 regardless of p53 status. Moreover, the changes in Bcl-2 protein were due to the increase in the transcriptional levels of Bcl-2 mRNA, based on real-time PCR assay. At the same time, BRCA1-deficient cells showed a greater apoptosis susceptibility to irradiation when compared with BRCA1-proficient cells. The results suggest that BRCA1 might exert p53-independent regulative activities for Bcl-2, which seems account for the low apoptosis susceptibility in BRCA1-proficient carcinomas.
Starting Page	916
Ending Page	922
Page Count	7
File Format	PDF
ISSN	16747348
Journal	Science in China Series G
Volume Number	54
Issue Number	5
e-ISSN	18691927
Language	English
Publisher	SP Science China Press
Publisher Date	2011-04-02
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	BRCA1 p53 Bax Bcl-2 apoptosis ionizing radiation Classical Continuum Physics Astronomy, Observations and Techniques Physics
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy

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Potential Mechanisms Involved in Resistant Phenotype of MCF-7 Breast Carcinoma Cells to Ionizing Radiation-Induced Apoptosis

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BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation

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BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation