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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Jiashen Li, Yi Zhang, Yu Liu, Xuan Zhao, Zheng Zhang, Jing Han, Yanxia Zhou, Dangxia |
| Description | Country affiliation: Hong Kong Author Affiliation: Li J ( Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong.) |
| Abstract | The cytotoxicity of wool polypeptide has been evaluated by both cell and animal models. Wool was dissolved in sodium hydroxide solution, the pH value of the solution was adjusted to 5.55 and the precipitate was harvested as wool polypeptide. The spray-dried polypeptide was collected as powders and characterized by SEM, FTIR and TG-DSC. The cell culturing results showed that wool polypeptide had no obvious negative effect on cell viability in vitro. Both acute oral toxicity and subacute 30-day oral toxicology studies showed that wool polypeptide had no influence on body weight, feed consumption, blood chemistry, and hematology at any dose levels. There were no treatment related findings on gross or detailed necroscopy, organ weights, organ/body weight ratios and histology. Our study indicated the absence of toxicity in wool polypeptide and supported its safe use as a food ingredient or drug carrier. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 57 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Peptides Isolation & Purification Toxicity Wool Chemistry Administration, Oral Animals Blood Chemical Analysis Body Weight Drug Effects Cells, Cultured Dose-response Relationship, Drug Eating Female Fibroblasts Food Safety Humans Hydrogen-ion Concentration Male Mice, Inbred Icr Microscopy, Electrochemical, Scanning Administration & Dosage Powders Analysis Pharmacology Protein Hydrolysates Rats, Sprague-dawley Spectroscopy, Fourier Transform Infrared Toxicity Tests, Subacute Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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