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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kullik, K. Brosig, B. Kersten, S. Valenta, H. Diesing, A-K Panther, P. Reinhardt, N. Kluess, J. Rothkötter, H-J Breves, G. Dänicke, S. |
| Description | Country affiliation: Germany Author Affiliation: Kullik K ( Institute of Animal Nutrition, Friedrich-Loeffler Institute, Federal Research Institute for Animal Health, Braunschweig, Germany.) |
| Abstract | The in vivo effects of the Fusarium toxin deoxynivalenol (DON) on albumin and fibrinogen synthesis in pigs and metabolic activity of porcine peripheral blood mononuclear cells (PBMCs) were studied alone or in combination with lipopolysaccharides (LPSs) in order to examine proposed synergistic effects of both substances. A total of 36 male castrated pigs (initial weight of 26 kg) were used. Uncontaminated (Control) and naturally DON-contaminated (chronic oral DON, 3.1mg/kg diet) wheat was fed for 37 days. On the day of protein synthesis measurement, pigs recruited from the Control group were treated once intravenously with (iv) DON (100 µg/kg live weight (LW)/h), iv LPS (7.5 µg/kgLW/h) or a combination of both substances, and six pigs from the chronic oral group were treated once with iv LPS. A treatment with DON alone exhibited no alterations of acute phase protein synthesis and metabolic activity of PBMC. There was no evidence that the chosen dosing regimen of DON had influences on the induced sub-acute stage of sepsis, as the LPS challenge, irrespective of DON co-exposure, mediated an acute phase reaction with a typical decrease of albumin synthesis, as well as changes in cytokine concentration and a loss of metabolic activity in PBMC. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 57 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Acute-phase Proteins Biosynthesis Cytokines Metabolism Leukocytes, Mononuclear Drug Effects Lipopolysaccharides Pharmacology Mycotoxins Swine Trichothecenes Albumins Animal Feed Animals Fibrinogen Food Contamination Fusarium Chemistry Male Analysis Triticum Microbiology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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