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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hayano, Yuki Zhao, Hong Kobayashi, Hiroaki Takeuchi, Kosei Norioka, Shigemi Yamamoto, Nobuhiko |
| Description | Country affiliation: Japan Author Affiliation: Hayano Y ( Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.); Zhao H ( Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.); Kobayashi H ( Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.); Takeuchi K ( Department of Biology, Aichi Medical University, Karimata-Yazako, Nagakute, Aichi 480-1195, Japan.); Norioka S ( Laboratories of Biomolecular Networks, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.); Yamamoto N ( Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan nobuhiko@fbs.osaka-u.ac.jp.) |
| Abstract | Cortical efferent and afferent fibers are arranged in a stereotyped pattern in the intermediate zone (IZ). Here, we studied the mechanism of axonal pathway formation by identifying a molecule that is expressed in a subset of cortical axons in the rat. We found that T-cadherin (T-cad), a member of the cadherin family, is expressed in deep-layer cell axons projecting to subcortical structures, but not in upper layer callosal axons projecting to the contralateral cortex. Ectopic expression of T-cad in upper layer cells induced axons to project toward subcortical structures via the upper part of the IZ. Moreover, the axons of deep-layer cells in which T-cad expression was suppressed by RNAi projected towards the contralateral cortex via an aberrant route. These results suggest that T-cad is involved in axonal pathway formation in the developing cortex. |
| File Format | HTM / HTML |
| ISSN | 09501991 |
| e-ISSN | 14779129 |
| Journal | Development |
| Issue Number | 24 |
| Volume Number | 141 |
| Language | English |
| Publisher | The Company of Biologists |
| Publisher Date | 2014-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Developmental Discipline Biology Axons Physiology Cadherins Metabolism Neocortex Cytology Growth & Development Neural Pathways Amino Acid Sequence Animals Animals, Newborn Blotting, Western Electrophoresis, Polyacrylamide Gel Electroporation Immunohistochemistry In Situ Hybridization Molecular Sequence Data Rna Interference Sequence Analysis, Protein Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Molecular Biology |
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