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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khan, Shahanavaj Ansari, Anees A. Khan, Azmat Ali Abdulla, Maha Al-Obaid, Omar Ahmad, Rehan |
| Description | Author Affiliation: Khan S ( Nanomedicine & Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: khan.shahanavaj@gmail.com.); Ansari AA ( King Abdullah Institute for Nanotechnology, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.); Khan AA ( Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2455, Riyadh, Saudi Arabia.); Abdulla M ( Colorectal Research Centre, College of Medicine, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.); Al-Obaid O ( Colorectal Research Centre, College of Medicine, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.); Ahmad R ( Colorectal Research Centre, College of Medicine, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.) |
| Abstract | Copper oxide nanoparticles (CuO-NPs) were synthesized using a urea-based thermal decomposition technique, and characterized using different techniques. X-ray diffraction (XRD) and Raman spectroscopy confirmed the phase purity and crystalline structure of CuO-NPs. The size of CuO-NPs was investigated using XRD and was confirmed via dynamic light scattering analysis. CuO-NPs showed an average diameter of â¼20nm. The possible cytotoxicity of CuO-NPs was evaluated in HT-29 and SW620 cancer cell lines. The median inhibitory concentration of CuO-NPs in HT-29 and SW-620 cells was 4.99 and 3.75µg/mL, respectively. The underlying mechanism responsible for apoptosis in colon cancer cells after CuO-NP exposure has not been well understood. In this study, we investigated the possible mechanisms of induction of apoptosis via analysis of the expression of Bcl-2 and Bcl-xL proteins in HT-29 human colon cancer cells after CuO-NP exposure. Western blot assay showed downregulation of Bcl-2 and Bcl-xL protein expression after CuO-NP exposure. Our findings may aid in the understanding of the potential mechanisms responsible for induction of apoptosis owing to inhibition of Bcl-2 and Bcl-xL protein expression. Furthermore, the antibacterial activity assay showed that the synthesized CuO-NPs did not exert significant inhibitory effects against different gram-positive and gram-negative bacteria in vitro. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume Number | 153 |
| e-ISSN | 18734367 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-06 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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