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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bahari, Leila Azharshekoufeh Javadzadeh, Yousef Jalali, Mohammad Barzegar Johari, Peyvand Nokhodchi, Ali Shokri, Javad |
| Description | Country affiliation: Iran Author Affiliation: Bahari LA ( Drug Applied Research Centre (DARC) and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.); Javadzadeh Y ( Drug Applied Research Centre (DARC) and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran); Jalali MB ( Drug Applied Research Centre (DARC) and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran); Johari P ( Drug Applied Research Centre (DARC) and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.); Nokhodchi A ( Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton, UK. Electronic address: a.nokhodchi@sussex.ac.uk.); Shokri J ( Drug Applied Research Centre (DARC) and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran) |
| Abstract | In controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging. Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former (sucrose or mannitol) in nano range was suspended in polymeric coating solution using ball-mill. The performance of the prepared formulations was assessed in terms of D (cumulative release percent after 12h), Dev (mean percent deviation of drug release from zero order kinetic), t (lag time of the drug release) and RSQ . The results revealed that gelling agent amount (HPMC E ) in core and pore former concentration in SPM had crucial effect on SPM integrity. All the optimised formulations showed a burst drug release due to fast dissolving nature of the pore formers. Results obtained from scanning electron microscopy demonstrated the formation of nanopores in the membrane where the drug release takes place via these nanopores. Nano suspension coating method can be introduced as novel method in formulation of CPOPs. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume Number | 153 |
| e-ISSN | 18734367 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-08 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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