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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yan, Junyan Chen, Liliang Huang, Chih-Ching Lung, Shih-Chun Candice Yang, Lingyan Wang, Wen-Cheng Lin, Po-Hsiung Suo, Guangli Lin, Chia-Hua |
| Description | Country affiliation: China Author Affiliation: Yan J ( Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China); Chen L ( The National Key Laboratory of Shock Wave and Detonation Physics, Instiute of Fluid Physics, CAEP, Mianyang 621900, China.); Huang CC ( Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan.); Lung SC ( Research Center for Environmental Changes, Academia Sinica, Taipei 11529, Taiwan.); Yang L ( Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.); Wang WC ( Research Center for Environmental Changes, Academia Sinica, Taipei 11529, Taiwan.); Lin PH ( Department of Environmental Engineering, National Chung Hsing University, Taichung, 402, Taiwan.); Suo G ( Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. Electronic address: glsuo2013@sinano.ac.cn.); Lin CH ( Department of Biotechnology, National Formosa University, Yunlin, 63208, Taiwan. Electronic address: vicchlin@nfu.edu.tw.) |
| Abstract | The biocompatibilities of graphene-family nanomaterials (GFNs) should be thoroughly evaluated before their application in drug delivery and anticancer therapy. The present study aimed to consecutively assess the immunotoxicity of graphene oxide nanoplatelets (GONPs) and reduced GONPs (rGONPs) on THP-1 cells, a human acute monocytic leukemia cell line. GONPs induced the expression of antioxidative enzymes and inflammatory factors, whereas rGONPs had substantially higher cellular uptake rate, higher levels of NF-κB expression. These distinct toxic mechanisms were observed because the two nanomaterials differ in their oxidation state, which imparts different affinities for the cell membrane. Because GONPs have a higher cell membrane affinity and higher impact on membrane proteins compared with rGONPs, macrophages (THP-1a) derived from GONPs treated THP-1cells showed a severer effect on phagocytosis. By consecutive evaluation the effects of GONPs and rGONPs on THP-1 and THP-1a, we demonstrated that their surface oxidation states may cause GFNs to behave differently and cause different immunotoxic effects. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume Number | 153 |
| e-ISSN | 18734367 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-02 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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