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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Huixue Cao, Yuze Chen, Lixia Wang, Jianjian Tian, Qinghua Wang, Ning Liu, Zhaojun Li, Jie Wang, Na Wang, Xiaokun Sun, Piyun Wang, Lihua |
| Description | Country affiliation: China Author Affiliation: Zhang H ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Cao Y ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China); Chen L ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. Electronic address: chenlixia_harbin@hotmail.com.); Wang J ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Tian Q ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Wang N ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Liu Z ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Li J ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Wang N ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Wang X ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Sun P ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.); Wang L ( Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. Electronic address: lh_wangchin@126.com.) |
| Abstract | One of the pathological hallmarks of Alzheimer's disease (AD) is the progressive accumulation of beta-amyloid (Aß) in the form of senile plaques, and Aß induced neurotoxicity has been identified as a major cause of the onset of AD. In this study, we investigated the protective effects of a polysaccharide (PS-WNP) from Polygonatum sibiricum against the Aß(25-35)-induced neurotoxicity in PC12 cells and explored the underlying mechanism. The results showed that pretreatment with PS-WNP significantly attenuated cell death and the elevated Bax/Bcl-2 ratio evoked by Aß(25-35), and subsequently inhibited mitochondrial dysfunction and cytochrome c release into the cytosol. Moreover, PS-WNP significantly inhibited Aß(25-35) induced caspase-3 activation and enhanced the protein levels of phosphorylated Akt (p-Akt) in PC12 cells. Additionally, pretreatment with the PI3K inhibitor (LY294002) completely abolished the protective effects of PS-WNP against Aß(25-35)-induced neuronal cell apoptosis. These observations unambiguously suggested that the protective effect of PS-WNP against Aß(25-35)-induced apoptosis in PC12 cells was associated with the enhancement of PI3K/Akt signaling pathway. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 117 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-06 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Amyloid Beta-peptides Toxicity Neurons Drug Effects Polygonatum Chemistry Polysaccharides Pharmacology Animals Apoptosis Caspase 3 Metabolism Cell Survival Cytochromes c Secretion Enzyme Activation Mitochondria Cytology Pc12 Cells Phosphatidylinositol 3-kinases Proto-oncogene Proteins C-akt Proto-oncogene Proteins C-bcl-2 Rats Rhizome Signal Transduction Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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