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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ehmann, Heike M. A. Breitwieser, Doris Winter, Sascha Gspan, Christian Koraimann, Günther Maver, Uros Sega, Marija Köstler, Stefan Stana-Kleinschek, Karin Spirk, Stefan Ribitsch, Volker |
| Description | Country affiliation: Austria Author Affiliation: Ehmann HM ( Institute for Chemistry, University of Graz, Graz, Austria); Breitwieser D ( Institute for Chemistry, University of Graz, Graz, Austria.); Winter S ( Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria.); Gspan C ( Institute for Electron Microscopy and Fine Structure Research, Centre for Electron Microscopy Graz, Graz, Austria.); Koraimann G ( Institute for Chemistry, University of Graz, Graz, Austria.); Maver U ( Faculty of Medicine, University of Maribor, Maribor, Slovenia.); Sega M ( Center of Transfusion Medicine, University Medical Centre Maribor, 2000 Maribor, Slovenia.); Köstler S ( Joanneum Research Materials, Institute for Surface Technologies, 8160 Weiz, Austria.); Stana-Kleinschek K ( Institute for the Engineering and Design of Materials, University of Maribor, Maribor, Slovenia.); Spirk S ( Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria); Ribitsch V ( Institute for Chemistry, University of Graz, Graz, Austria.) |
| Abstract | Simultaneous antibacterial and anticoagulant surfaces have been prepared by immobilization of engineered gold nanoparticles onto different kinds of surfaces. The gold nanoparticle core is surrounded by a hemocompatible, anticoagulant polysaccharide, 6-O chitosan sulfate, which serves as reduction and stabilizing agent for the generation of gold nanoparticles in a microwave mediated reaction. The particle suspension shows anticoagulant activity, which is investigated by aPTT and PT testing on citrated blood samples of three patients suffering from congenital or acquired bleeding disorders. The amount of nanoparticles deposited on the surfaces is quantified by a quartz crystal microbalance with dissipation unit. All gold containing surfaces exhibit excellent antimicrobial properties against the chosen model organism, Escherichia coli MG 1655 [R1-16]. Moreover, blood plasma coagulation times of the surfaces are increased after deposition of the engineered nanoparticles as demonstrated by QCM-D. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 117 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-06 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Anti-bacterial Agents Chemistry Pharmacology Anticoagulants Gold Metal Nanoparticles Capsules Cellulose Chitosan Engineering Escherichia Coli Drug Effects Humans Partial Thromboplastin Time Prothrombin Time Sulfates Surface Properties Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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