NDLI: SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells.

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SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jiang, Junjun Li, Liyuan Xie, Mingchao Fuji, Ryosuke Liu, Shangfeng Yin, Xiaobei Li, Genlin Wang, Zhao
Description	Author Affiliation: Jiang J ( MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University.)
Abstract	Spermatogenesis associated 4 (SPATA4) is a testis-specific gene first cloned by our laboratory, and plays an important role in maintaining the physiological function of germ cells. Accumulated evidence suggests that SPATA4 might be associated with apoptosis. Here we established HeLa cells that stably expressed SPATA4 to investigate the function of SPATA4 in apoptosis. SPATA4 protected HeLa cells from etoposide-induced apoptosis through the mitochondrial apoptotic pathway, in the way that SPATA4 suppressed decrease of the mitochondrial membrane potential, the release of cytochrome c, and subsequent activation of caspase-9 and -3. We further demonstrated that SPATA4 upregulated anti-apoptotic members of Bcl-2 family proteins, Bcl-2, and downregulated the pro-apoptotic member of Bcl-2 family proteins, Bax. Knockdown of SPATA4 in HeLa/SPATA4 cells could partially rescue expression levels of bcl-2 and bax. In conclusion, SPATA4 protects HeLa cells against etoposide-induced apoptosis through the mitochondrial apoptotic pathway. Our findings provide further evidence that SPATA4 plays a role in regulating apoptosis.
File Format	HTM / HTML
ISSN	09186158
e-ISSN	13475215
Journal	Biological & Pharmaceutical Bulletin
Issue Number	10
Volume Number	38
Language	English
Publisher	The Pharmaceutical Society of Japan J-STAGE
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Discipline Pharmacology Apoptosis Physiology Proteins Metabolism Proto-oncogene Proteins C-bcl-2 Drug Effects Caspase 3 Caspase 9 Cytochromes c Etoposide Hela Cells Membrane Potential, Mitochondrial Mitochondria Genetics Topoisomerase Ii Inhibitors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology Pharmaceutical Science

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SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells.