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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cooper, Peter D. Rajapaksha, K. Harinda Barclay, Thomas G. Ginic-Markovic, Milena Gerson, Andrea R. Petrovsky, Nikolai |
| Description | Author Affiliation: Cooper PD ( Vaxine Pty Ltd, Flinders Medical Centre, Bedford Park, SA, Australia 5042); Rajapaksha KH ( Vaxine Pty Ltd, Flinders Medical Centre, Bedford Park, SA, Australia 5042.); Barclay TG ( Mawson Institute, University of South Australia, Mawson Lakes, SA, Australia 5095.); Ginic-Markovic M ( Mawson Institute, University of South Australia, Mawson Lakes, SA, Australia 5095.); Gerson AR ( Mawson Institute, University of South Australia, Mawson Lakes, SA, Australia 5095.); Petrovsky N ( Vaxine Pty Ltd, Flinders Medical Centre, Bedford Park, SA, Australia 5042) |
| Abstract | Semi-crystalline microparticles of inulin (MPI) have clinical utility as potent human vaccine adjuvants but their relevant surface structure and crystal assembly remain undefined. We show inulin crystal surfaces to resemble multi-layered, discoid radial spherulites resulting from very rapid formation of complex tertiary structures, implying directed crystal initiation. Physical and in silico molecular modelling of unit cells confirm steric feasibility of initiation by hydrogen-bonded cross-linking of terminal glucose to a fructose of another chain, mimicking bonding in sucrose crystals. A strong, chelate-like dual H-bond is proposed to compel the known antiparallel alignment of inulin chains. Such cross-linking would require one extra fructose per chain in the native inulin crystal, as observed. Completion of five H-bonded internal ring-domains would 'lock in' each new 6-fructose structural unit of each antiparallel helix pair to create a new isoform. All known properties of inulin isoforms follow readily from these concepts. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| e-ISSN | 18791344 |
| DOI | 10.1016/j.carbpol.2014.10.022 |
| Journal | Carbohydrate Polymers |
| Volume Number | 117 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-06 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Fructose Chemistry Glucose Inulin Microscopy, Atomic Force Models, Molecular Carbohydrate Conformation Microspheres Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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