NDLI: Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure

Content Provider	Springer Nature : BioMed Central
Author	Caron, Laurence Delisle, Jean-Sébastien Strong, James E Deschambault, Yvon Lombard-Vadnais, Félix Labbé, Annie-Claude Lesage, Sylvie
Abstract	Background Lymphocytic choriomeningitis virus (LCMV) is a human pathogen naturally present in wild rodents. In addition, LCMV is routinely used in immunology research as a model of viral infection in mice. The Armstrong common laboratory strain and the Clone-13 variant induce acute and chronic infections in mice, respectively. The frequent use of this virus in laboratory settings is associated with a risk of human infection for laboratory personnel. In contrast to LCMV Clone-13, few human laboratory infections with LCMV Armstrong have been reported, leading to a poor understanding of symptoms related to infection with this specific LCMV strain. Case presentation A researcher accidentally infected herself percutaneously with LCMV Armstrong. Symptoms including headaches, dizziness, eye pain and nausea appeared seven days post-exposure and lasted ten days. LCMV-IgM antibodies were detected at 28 days post-infection and IgG seroconversion was observed later. Complete recovery was confirmed three months post exposure. Conclusions Research involving live viruses comes with the risk of infection for research personnel. This case is the first reported accidental human infection with LCMV Armstrong. The symptoms differed from reported infections with LCMV Clone-13, by the absence of fever and vomiting, and presence of leg numbness. This report will therefore help clinicians and public health authorities to recognize the symptoms associated with LCMV Armstrong infections and to offer appropriate counselling to individuals who accidentally expose themselves.
Related Links	https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-023-02258-x.pdf
Ending Page	4
Page Count	4
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12985-023-02258-x
Journal	Virology Journal
Issue Number	1
Volume Number	20
Language	English
Publisher	BioMed Central
Publisher Date	2023-12-12
Access Restriction	Open
Subject Keyword	Virology LCMV Armstrong Laboratory accidental exposure
Content Type	Text
Resource Type	Case study
Subject	Virology Infectious Diseases
Journal Impact Factor	4/2023
5-Year Journal Impact Factor	3.8/2023

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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