NDLI: Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

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Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

Content Provider	Scilit
Author	Ahmed, R. Salmi, A. Butler, L. D. Chiller, J. M. Oldstone, M. B.
Copyright Year	1984
Description	We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB/c WEHI mice infected at birth with LCMV Armstrong strain. Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV-specific CTL response of spleen cells from normal adult mice. The suppression was specific for the CTL response and LCMV -specific antibody responses were not affected. Associated with the specific CTL suppression was the establishment of persistent LCMV infection. The transfer of spleen or lymph node cells containing LCMV -specific CTL resulted in virus clearance and prevented establishment of the carrier state. The suppression of LCMV -specific CTL responses by carrier spleen cells is not mediated by a suppressor cell, but is due to the presence of genetic variants of LCMV in spleens of carrier mice. Such virus variants selectively suppress LCMV-specific CTL responses and cause persistent infections in immunocompetent mice. In striking contrast, wild-type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly cleared. Our results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus-specific CTL responses and in the maintenance of virus persistence.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187458/pdf
Ending Page	540
Page Count	20
Starting Page	521
DOI	10.1084/jem.160.2.521
Journal	The Journal of experimental medicine
Issue Number	2
Volume Number	160
Language	English
Publisher	Rockefeller University Press
Publisher Date	1984-08-01
Access Restriction	Open
Subject Keyword	Virology Virus Genetic Variants Spleen Lcmv Infection Persistently Infected Lcmv Specific Lcmv Armstrong Journal: The Journal of experimental medicine (Vol- 160, Issue- 2)
Content Type	Text

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