NDLI: Cross-reactive immune responses to monkeypox virus induced by MVA vaccination in mice

Content Provider	Springer Nature : BioMed Central
Author	Gao, Feixia He, Cheng Liu, Min Yuan, Ping Tian, Shihua Zheng, Mei Zhang, Linya Zhou, Xu Xu, Fangjingwei Luo, Jian Li, Xiuling
Abstract	Mpox (monkeypox) infection cases increased recently in non-Mpox outbreak areas, potentially causing an international threat. The desire to defend against a potential outbreak has led to renewed efforts to develop Mpox vaccines. In this report, mice were immunized with various doses of modified vaccinia virus Ankara (MVA) to evaluate the cross-reactive immune response of MVA immunization against protective antigens of the current monkeypox virus. We demonstrated that MVA induced specific antibodies against protective antigens (A29, A35, B6, M1, H3, and I1), mediating the neutralization abilities against the MVA and the monkeypox virus (MPXV). Moreover, recombinant protective antigens of the MPXV elicited cross-binding and cross-neutralizing activities for MVA. Hence, the MVA induced cross-reactive immune responses, which may guide future efforts to develop vaccines against the recent MPXV. Notably, compared to the other protective antigens, the predominant A29 and M1 antigens mediated higher cross-neutralizing immune responses against the MVA, which could serve as antigen targets for novel orthologous orthopoxvirus vaccine.
Related Links	https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-023-02085-0.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12985-023-02085-0
Journal	Virology Journal
Issue Number	1
Volume Number	20
Language	English
Publisher	BioMed Central
Publisher Date	2023-06-19
Access Restriction	Open
Subject Keyword	Virology MVA Monkeypox virus Protective antigens Humoral immune response Cellular immune response
Content Type	Text
Resource Type	Article
Subject	Virology Infectious Diseases
Journal Impact Factor	4/2023
5-Year Journal Impact Factor	3.8/2023

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