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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zhang, Huan Jiang, Yushan Tan, Hanqing Zou, Lirong Zheng, Zhonghua Huang, Yushi Lin, Shujian Su, Lebin Yu, Jianxiang Deng, Xiaoling He, Jianfeng Liu, Chang Shen, Chenguang Li, Baisheng |
| Abstract | Currently, the majority of the global population has been vaccinated with the COVID-19 vaccine, and characterization studies of antibodies in vivo from Omicron breakthrough infection and naive infection populations are urgently needed to provide pivotal clues about accurate diagnosis, treatment, and next-generation vaccine design against SARS-CoV-2 infection. We showed that after infection with Omicron-BA.2, the antibody levels of specific IgM against the Wuhan strain and specific IgG against Omicron were not significantly elevated within 27 days of onset. Interestingly, in this study, the levels of humoral immunity against Omicron-specific IgM were significantly increased after breakthrough infection, suggesting that the detection of Omicron-specific IgM antibodies can be used as a test criterion of Omicron breakthrough infection. In addition, we observed that serums from unvaccinated individuals and the majority of vaccinated infections possessed only low or no neutralizing activity against Omicron at the onset of Omicron breakthrough infections, and at the later stage of Omicron-BA.2 breakthrough infection, levels of neutralization antibody against the Wuhan and Omicron strains were elevated in infected individuals. The findings of this study provide important clues for the diagnosis of Omicron breakthrough infections, antibody characterization studies and vaccine design against COVID-19. |
| Related Links | https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-022-01912-0.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12985-022-01912-0 |
| Journal | Virology Journal |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-11-25 |
| Access Restriction | Open |
| Subject Keyword | Virology Omicron-BA.2 Breakthrough infection Antibody responses IgM Neutralization antibody |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Infectious Diseases |
| Journal Impact Factor | 4/2023 |
| 5-Year Journal Impact Factor | 3.8/2023 |
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