NDLI: Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults

Content Provider	Springer Nature : BioMed Central
Author	Choi, Wonsuk Park, Minae Park, Sojeong Park, Ji Yong Hong, A Ram Yoon, Jee Hee Ha, Kyoung Hwa Kim, Dae Jung Kim, Hee Kyung Kang, Ho-Cheol
Abstract	Objectives This study aimed to investigate the impact of hepatic steatosis on cardiometabolic outcomes in young adults with prediabetes. Methods A nationwide cohort study was conducted with 896,585 young adults under 40 years old without diabetes or previous history of cardiovascular disease. Hepatic steatosis was identified using a fatty liver index of ≥ 60. The outcomes of this study were incident diabetes (DM) and composite major adverse cardiovascular events (MACE), including myocardial infarction, stroke, or cardiovascular death. Results During a median follow-up of 11.8 years, 27,437 (3.1%) incident DM cases and 6,584 (0.7%) MACE cases were recorded. Young adults with prediabetes had a significantly higher risk of incident DM (hazard ratio [HR]: 2.81; 95% confidence interval [CI]: 2.74–2.88; P-value: <0.001) and composite MACE risk (HR: 1.10; 95% CI: 1.03–1.17; P-value: 0.003) compared to individuals with normoglycemia, after adjusting for relevant covariates. Stratification based on hepatic steatosis showed that the combination of prediabetes and hepatic steatosis posed the highest risk for these outcomes, after adjusting for relevant covariates. For incident DM, the HRs (95% CI; P-value) were: 3.15 (3.05–3.26; <0.001) for prediabetes without hepatic steatosis, 2.89 (2.78–3.01; <0.001) for normoglycemia with hepatic steatosis, and 6.60 (6.33–6.87; <0.001) for prediabetes with hepatic steatosis. For composite MACE, the HRs (95% CI; P-value) were 1.05 (0.97–1.13; 0.235) for prediabetes without hepatic steatosis, 1.39 (1.27–1.51; <0.001) for normoglycemia with hepatic steatosis, and 1.60 (1.44–1.78; <0.001) for prediabetes with hepatic steatosis. Conclusions Prediabetes and hepatic steatosis additively increased the risk of cardiometabolic outcomes in young adults. These findings hold significance for physicians as they provide insights into assessing high-risk individuals among young adults with prediabetes.
Related Links	https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-024-02516-4.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	14752840
DOI	10.1186/s12933-024-02516-4
Journal	Cardiovascular Diabetology
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2024-11-21
Access Restriction	Open
Subject Keyword	Diabetes Angiology Cardiology Prediabetes Hepatic steatosis Young adults Cardiometabolic disease Cohort analysis
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism
Journal Impact Factor	8.5/2023
5-Year Journal Impact Factor	8.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes: KORA F4/FF4 cohort study

Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants

Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis

Serum ferritin and incident cardiometabolic diseases in Scottish adults

Prognostic impact of liver fibrosis and steatosis by transient elastography for cardiovascular and mortality outcomes in individuals with nonalcoholic fatty liver disease and type 2 diabetes: the Rio de Janeiro Cohort Study

Correction: Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Statins in cardiometabolic disease: what makes pitavastatin different?

Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography

Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults

Similar Documents

Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes: KORA F4/FF4 cohort study

Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants

Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis

Serum ferritin and incident cardiometabolic diseases in Scottish adults

Prognostic impact of liver fibrosis and steatosis by transient elastography for cardiovascular and mortality outcomes in individuals with nonalcoholic fatty liver disease and type 2 diabetes: the Rio de Janeiro Cohort Study

Correction: Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Statins in cardiometabolic disease: what makes pitavastatin different?

Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography

Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults