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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Taktaz, Fatemeh Fontanella, Rosaria Anna Scisciola, Lucia Pesapane, Ada Basilicata, Manuela Giovanna Ghosh, Puja Franzese, Martina Tortorella, Giovanni Puocci, Armando Vietri, Maria Teresa Capuano, Annalisa Paolisso, Giuseppe Barbieri, Michelangela |
| Abstract | Tirzepatide is a new drug targeting glucagon-like peptide 1(GLP1) and gastric inhibitory polypeptide (GIP) receptors. This drug has demonstrated great potential in improving the clinical outcomes of patients with type 2 diabetes. It can lead to weight loss, better glycemic control, and reduced cardiometabolic risk factors. GLP1 receptor agonists have been proven effective antidiabetic medications with possible cardiovascular benefits. Even though they have been proven to reduce the risk of major adverse cardiovascular events, their effectiveness in treating heart failure is unknown. Unlike traditional GLP1 receptor agonists, tirzepatide is more selective for the GIP receptor, resulting in a more balanced activation of these receptors. This review article discusses the possible mechanisms tirzepatide may use to improve cardiovascular health. That includes the anti-inflammatory effect, the ability to reduce cell death and promote autophagy, and also its indirect effects through blood pressure, obesity, and glucose/lipid metabolism. Additionally, tirzepatide may benefit atherosclerosis and lower the risk of major adverse cardiac events. Currently, clinical trials are underway to evaluate the safety and efficacy of tirzepatide in patients with heart failure. Overall, tirzepatide’s dual agonism of GLP1 and GIP receptors appears to provide encouraging cardiovascular benefits beyond glycemic control, offering a potential new therapeutic option for treating cardiovascular diseases and heart failure. Graphical abstract |
| Related Links | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-024-02319-7.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752840 |
| DOI | 10.1186/s12933-024-02319-7 |
| Journal | Cardiovascular Diabetology |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-07-10 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Angiology Cardiology Tirzepatide GLP-1 receptor GIP receptor GLP1 receptor agonists Heart failure |
| Content Type | Text |
| Resource Type | Review |
| Subject | Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism |
| Journal Impact Factor | 8.5/2023 |
| 5-Year Journal Impact Factor | 8.9/2023 |
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