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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Guo, Bei Zhuang, Tong-Tian Li, Chang-Chun Li, Fuxingzi Shan, Su-Kang Zheng, Ming-Hui Xu, Qiu-Shuang Wang, Yi Lei, Li-Min Tang, Ke-Xin Ouyang, Wenlu Duan, Jia-Yue Wu, Yun-Yun Cao, Ye-Chi Ullah, Muhammad Hasnain Ehsan Zhou, Zhi-Ang Lin, Xiao Wu, Feng Xu, Feng Liao, Xiao-Bo Yuan, Ling-Qing |
| Abstract | Background Visceral adipose tissue in individuals with obesity is an independent cardiovascular risk indicator. However, it remains unclear whether adipose tissue influences common cardiovascular diseases, such as atherosclerosis, through its secreted exosomes. Methods The exosomes secreted by adipose tissue from diet-induced obesity mice were isolated to examine their impact on the progression of atherosclerosis and the associated mechanism. Endothelial apoptosis and the proliferation and migration of vascular smooth muscle cells (VSMCs) within the atherosclerotic plaque were evaluated. Statistical significance was analyzed using GraphPad Prism 9.0 with appropriate statistical tests. Results We demonstrate that adipose tissue-derived exosomes (AT-EX) exacerbate atherosclerosis progression by promoting endothelial apoptosis, proliferation, and migration of VSMCs within the plaque in vivo. MicroRNA-132/212 (miR-132/212) was detected within AT-EX cargo. Mechanistically, miR-132/212-enriched AT-EX exacerbates palmitate acid-induced endothelial apoptosis via targeting G protein subunit alpha 12 and enhances platelet-derived growth factor type BB-induced VSMC proliferation and migration by targeting phosphatase and tensin homolog in vitro. Importantly, melatonin decreases exosomal miR-132/212 levels, thereby mitigating the pro-atherosclerotic impact of AT-EX. Conclusion These data uncover the pathological mechanism by which adipose tissue-derived exosomes regulate the progression of atherosclerosis and identify miR-132/212 as potential diagnostic and therapeutic targets for atherosclerosis. Graphical Abstract |
| Related Links | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-024-02404-x.pdf |
| Ending Page | 20 |
| Page Count | 20 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752840 |
| DOI | 10.1186/s12933-024-02404-x |
| Journal | Cardiovascular Diabetology |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-09-09 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Angiology Cardiology Adipose tissue Atherosclerosis Melatonin MiR-132/212 Obesity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism |
| Journal Impact Factor | 8.5/2023 |
| 5-Year Journal Impact Factor | 8.9/2023 |
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