NDLI: Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis

Content Provider	Springer Nature : BioMed Central
Author	Ouyang, Zan Chen, Ping Zhang, Min Wu, Sijia Qin, Zongying Zhou, Li
Abstract	Background The aim of this study is to investigate the impact of arginine on immune function and postoperative complications in colorectal cancer (CRC) patients. Methods We conducted a comprehensive search to identify eligible RCTs in various databases, such as PubMed, Cochrane Library, EMBASE, Web of Science, MEDLINE, China National Knowledge Infrastructure (CNKI), Wanfang, VIP Medicine Information System (VIP), and Chinese Biomedical Database (CBM). This study aimed to examine IgA, IgG, and IgM levels as well as CD4+ and CD8+ counts as well as the CD4+/CD8+ ratio. Anastomotic leaking, length of stay (LOS), and surgical site infection (SSI) were included as secondary outcomes. Stata (StataCorp, version 14.0) was utilized for data analysis. To ensure the results were reliable, we used meta-regression, sensitivity analysis, and publication bias analysis. Results A total of 24 publications (including 1883 patients) out of 681 that were retrieved fulfilled the inclusion criteria. The arginine group showed notable improvements in humoral immunity, with gains in IgA (SMD=0.45, 95% CI: 0.30-0.60), IgG (SMD=0.80, 95% CI: 0.64-0.96), and IgM (SMD=0.66, 95% CI: 0.39-0.93). With regards to cellular immunity, the arginine group exhibited a substantial increase in the CD4+ T cell count (SMD = 1.03, 95% CI: 0.67-1.38) compared to the control group. However, the CD4+/CD8+ ratio decreased significantly (SMD=1.37, 95% CI: 0.88-1.86) in the same arginine group, indicating a change in the balance between these two cell types. Additionally, the CD8+ T cell count showed a notable decrease (SMD=-0.70, 95% CI: -1.09 to -0.32) in the arginine group when compared to the control group. Anastomotic leakage was also considerably lower in the arginine group (SMD=-0.05, 95% CI: -0.08 to -0.02), the rate of SSIs was lower (RR = -0.02, 95% CI: -0.05-0), and the length of time patients spent in the hospital was shorter (SMD=-0.15, 95% CI: -0.38 to -0.08). Conclusions After radiation treatment for CRC, arginine improves immune function and decreases the risk of infection problems. Trial registration Registration with PROSPERO for this meta-analysis is number CRD42024520509.
Related Links	https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-024-12858-7.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	14712407
DOI	10.1186/s12885-024-12858-7
Journal	BMC Cancer
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-09-02
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Surgical Oncology Health Promotion and Disease Prevention Biomedicine Medicine Public Health Colorectal cancer Arginine Immune function Post-operative complications Meta-analysis Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology Genetics
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	3.8/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Immune characterization of metastatic colorectal cancer patients post reovirus administration

The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment

Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis

Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis

The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

Artificial intelligence for pre-operative lymph node staging in colorectal cancer: a systematic review and meta-analysis

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer

Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis

Similar Documents

Immune characterization of metastatic colorectal cancer patients post reovirus administration

The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment

Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis

Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis

The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

Artificial intelligence for pre-operative lymph node staging in colorectal cancer: a systematic review and meta-analysis

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer

Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis