NDLI: Characteristics and patient-reported outcomes of long-term cancer survivors after apatinib-based therapy: an online survey

Content Provider	Springer Nature : BioMed Central
Author	Zhang, Tingting Meng, Chao He, Wei Xu, Tao Yang, Yi Tu, Chongqi Zhang, Ling Sun, Xiaofeng Zhu, Chunrong Dang, Xueyi Wang, Ke Chen, Chuan Yan, Xiong Xu, Huiting Huang, Le Jiang, Enlai Xia, Feng Zhou, Xinming Zhou, Shunkai Zang, Weidong Li, Xifeng Zhang, Jin Zheng, Jiaping Xin, Jianjun Huang, Bin Zhu, Guopei Zhu, Jiexiang Liang, Jun
Abstract	Background Data on long-term cancer survivors treated with apatinib are lacking. This study aimed to describe the characteristics of long-term cancer survivors after apatinib-based therapy, and to know about their satisfaction degree with apatinib and severity of depression and insomnia. Methods Patients with solid tumors who had received apatinib-based therapy for at least 5 years were invited to complete an online questionnaire. Characteristics of patients and treatment, knowledge of apatinib, satisfaction degree, and severity of depression and insomnia assessed by Patient Health Questionnaire-9 and Insomnia Severity Index were collected. Results Between December 8, 2023 and March 1, 2024, a total of 436 patients completed the online questionnaire. Most patients were satisfied with the efficacy (96.6%) and safety (93.1%) of apatinib, were willing to continue apatinib treatment (99.5%), and would recommend apatinib to other patients (93.3%). Continuous apatinib treatment resulted in significant negative impact on daily life, work, or study in only two (0.5%) patients. Almost all patients currently had no or mild depression (97.0%) and insomnia (97.9%) problems. The most common patient-reported adverse events were hand-foot syndrome (21.3%) and hypertension (18.3%). Conclusions Our survey showed a high satisfaction degree with apatinib in long-term cancer survivors. Long-term apatinib treatment resulted in almost no negative impact on patient’s quality of life.
Related Links	https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-024-12832-3.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	14712407
DOI	10.1186/s12885-024-12832-3
Journal	BMC Cancer
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-08-31
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Surgical Oncology Health Promotion and Disease Prevention Biomedicine Medicine Public Health Apatinib Cancer Depression Insomnia Survey Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology Genetics
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	3.8/2023

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